OBJECTIVE Ambient hypoxia impairs the airway epithelial Na transport, which is crucial in lung edema reabsorption. Whether chronic systemic hypoxemia affects airway Na transport has remained largely unknown. We have therefore investigated whether chronic systemic hypoxemia in children with congenital heart defect affects airway epithelial Na transport, Na transporter-gene expression, and short-...

A case of congenital aneurysm of the pulmonary sinus (sinus of Valsalva) in a 7-year-old child is described. The child met a traumatic death and manifested no symptoms or definite signs of his valvular defect. The heart was of normal weight, and no other abnormalities of the heart or other organs were present. This is the first report of sinus aneurysm of the pulmonary valve. The pathogenetic i...

We investigated the impact of heart defects on the developing human fetus by examining 412 hearts from consecutive spontaneous abortuses. In each case, the cardiac morphology was correlated with the autopsy findings and the karyotype (unavailable in 115 hearts not successfully cultured). Of the 412 hearts, 10 (2.4%) contained structural defects (six ventricular septal defects, one atrial septal...

Is the most common congenital defect in dogs. It is a LR shunting defect resulting from failure of closure of the left sixth aortic arch. If left untreated it results in left sided congestive heart failure. Clinically animals present with a Continuous (Machinery) Murmur at the left heart base with Hyperkinetic Femoral Pulses. A systolic murmur of mitral regurgitation may also be ausculted secon...

A case report of a 28-year-old patient, who presented with symptoms and signs of congestive heart failure and had clinical signs of ventricular septal defect as well. On further work-up echocardiogram showed non-compaction of the left ventricle with severe left ventricular systolic dysfunction and a ventricular septal defect. He was treated with standard treatment of heart failure and is doing ...

A case of congenital aneurysm of the pulmonary sinus (sinus of Valsalva) in a 7-year-old child is described. The child met a traumatic death and manifested no symptoms or definite signs of his valvular defect. The heart was of normal weight, and no other abnormalities of the heart or other organs were present. This is the first report of sinus aneurysm of the pulmonary valve. The pathogenetic i...

Many patients with congenital heart disease and systemic-to-pulmonary shunts develop pulmonary arterial hypertension (PAH), particularly if the cardiac defect is left unrepaired. A persistent increase in pulmonary blood flow may lead to obstructive arteriopathy and increased pulmonary vascular resistance, a condition that can lead to reversal of shunt and cyanosis (Eisenmenger syndrome). Cardia...

Primary cardiac tumor in infancy is an uncommon condition which is rarely accompanied with congenital heart disease. Although these tumors are generally benign, the complication associated with it, such as arrhythmia, outflow tract obstruction, and heart failure, may result in early mortality, when combined with congenital heart disease. Early surgical treatment may reduce complication risk and...

RATIONALE Brugada syndrome (BrS) is a cardiac ion channel disease that is caused by an autosomal dominant genetic abnormality. A ventricular septal defect is a common congenital heart disease, in which genetic defects play a significant role. PATIENT CONCERNS We report an extremely rare case of a 42-year-old male with congenital heart disease, who suffered recurrent syncope and gastrointestin...