OBJECTIVES Hemorrhagic shock followed by resuscitation (HSR) commonly triggers an inflammatory response that leads to acute respiratory distress syndrome. HYPOTHESIS HSR exacerbates mechanical stress-induced lung injury by rendering the lung more susceptible to ventilator-induced lung injury. METHODS Rats were subjected to HSR, and were randomized into an HSR + high tidal volume and zero po...

OBJECTIVE Avoiding abacavir in HIV-infected patients tested positive for HLA-B*5701 reduces the risk of abacavir hypersensitivity reaction (ABC-HSR). Our aim was to assess the costs of clinically suspected HSR and to estimate potential cost savings of implementing prospective HLA-B*5701-screening for HIV-infected patients initiating abacavir/lamivudine fixed-dose combination (ABC/3TC FDC) compa...

This paper describes the implementation of the Portuguese High Speed Rail (HSR) Network. The business model developed by RAVE for the PPP's related with the HSR infrastructure is described and discussed. Following a recently awarded research project (EXPRESS) aimed at studying the strategic aspects related with the implementation of HSR is presented and its aspects more directly related with HS...

background: blood viscosity and aortic sclerosis (as) are strong predictors of cardiovascular events. the effects of blood viscosity on as have not been studied adequately. we aimed to investigate the potential connection between whole blood viscosity (wbv) and as. methods:   as was detected by transthoracic echocardiography. the estimation of wbv was carried out at both high shear rate (hsr) (...

The heat shock response (HSR) is an evolutionarily conserved molecular/biochemical reaction to thermal stress that is essential to the survival of eukaryotic organisms. Recessive Mutator transposon mutations at the maize empty pericarp2 (emp2) locus led to dramatically increased expression of heat shock genes, retarded embryo development, and early-stage abortion of embryogenesis. The developme...