Ependymoma constitute 5 % to 7 % of all primary CNS neoplasm. But their prevalence relative to other tumor type varies with patient age and presenting location. Ependymoma constitute approximately 1O % of intracranial neoplasm in pediatric population and up to 30 % of those encountered in children under 3 years of age. In spinal column, ependymoma constitute 60% of glial neoplasm, and opposed...

originally published doi:10.1182/blood-2013-11-492231 2014 123: 2625-2635 Marcela V. Maus, Stephan A. Grupp, David L. Porter and Carl H. June malignancies Antibody-modified T cells: CARs take the front seat for hematologic http://bloodjournal.hematologylibrary.org/content/123/17/2625.full.html Updated information and services can be found at: (25 articles) Review Series (507 articles) Review A...

Ovarian cancer is characterized by the highest mortality rate among gynecologic malignancies. Therefore, there is a growing need for innovative therapies and techniques for monitoring and prevention of this disease. The exact cause of most ovarian tumors usually remains unknown. Ovarian cancer is believed to be caused by a range of different variables. This review is an attempt to summarize som...

BACKGROUND The nucleoporin gene NUP98 is rearranged in more than 27 chromosomal abnormalities observed in childhood and adult, de novo and therapy-related acute leukemias of myeloid and T-lymphoid origins, resulting in the creation of fusion genes and the expression of chimeric proteins. We report here the functional analysis of the NUP98-coiled-coil domain-containing protein 28A (NUP98-CCDC28A...

A population-based case-control study was conducted to evaluate risk of developing multiple myeloma (MM) associated with personal history of autoimmune diseases and occurrence of autoimmune and selected hematologic disorders in first-degree relatives. Data were obtained for all (n = 8,406) MM cases diagnosed in Sweden (1958-1998), with linkable relatives, 16,543 matched controls and first-degre...

PURPOSE Acute myeloid leukemia (AML) is an aggressive hematologic neoplasm. Recent evidence has shown the bone marrow microenvironment in patients with AML to be intrinsically hypoxic. Adaptive cellular responses by leukemia cells to survive under low oxygenation also confer chemoresistance. We therefore asked whether therapeutic exploitation of marrow hypoxia via the hypoxia-activated nitrogen...

PURPOSE The aim of this study was to define the risk of second cancer in nongastric marginal zone lymphomas of mucosa-associated lymphoid tissue (MALT). EXPERIMENTAL DESIGN We considered for the analysis 157 patients with a confirmed histology of marginal zone B-cell lymphoma of MALT, presenting with a clinically prevalent extranodal site of disease, except for stomach. All patients came from...

1Department of Molecular Immunology, Virology and Medical Genetics, The Ohio State University, Columbus, OH; 2Department of Experimental and Clinical Medicine, University Magna Græcia of Catanzaro, Catanzaro, Italy; 3Division of Experimental Oncology 2 Centro di Riferimento Oncologico, Aviano, Italy; 4Department of Medicine, University of California at San Diego, La Jolla, CA; and 5Lautenberg C...

BACKGROUND Human T-lymphotropic virus type 1 (HTLV-1) was the first retrovirus identified in human. The current evidence is quite scarce regarding the potential role of HTLV-1 in pathogenesis of hematologic disorders and non-hematologic malignancies. OBJECTIVES The aim of this study is to evaluate the prevalence of HTLV-1 infection in patients with hematologic disorders and non-hematologic ma...

BACKGROUND In the 2008 World Health Organization classification, small lymphocytic lymphoma is defined as a neoplasm with the tissue morphology and immunophenotype of chronic lymphocytic leukemia, but with absence of leukemia. Minimal criteria of tissue involvement to separate small lymphocytic lymphoma from monoclonal B-cell lymphocytosis have not been defined. DESIGN AND METHODS We reviewed...