PURPOSE OF REVIEW Provides an update of hematopoietic stem cell transplantation for systemic sclerosis from phase I/II studies and prospective randomized phase III trials, and introduces the concept of mesenchymal stem cells as potential therapy for autoimmune disease. RECENT FINDINGS Around 170 transplanted systemic sclerosis patients are registered in Europe. Most received autologous, perip...

Objectives: Graft versus host disease (GVHD) is a life threatening reaction in the stem cell transplantation process. Nowadays Cyclosporine is the most commonly utilized agent for GVHD prophylaxis and it has a major role in successful transplantation. Cyclosporine has been applied for many years in this field but it could be stated that currently no general consensus is available for its optima...

AIM To study the short tandem repeat (STR) pattern of DNA from the blood, buccal swabs, and hair follicles of the recipients of allogenic hematopoietic stem cell transplantation to examine whether these tissues contain donor derived cells. METHODS The study enrolled 25 patients who sustained engraftment. Peripheral blood, buccal swabs, and hair follicles were collected on days 21-30, 90, and ...

The use of high dose chemotherapy followed by autologous hematopoietic stem cell transplantation for remission consolidation after initial induction represents standard of care for patients with multiple myeloma. Patients with myeloma and Acquired von Willebrand Syndrome (AVWS) undergoing autologous stem cell transplant (ASCT) are at significant risk of bleeding due to the profound thrombocytop...

In hematopoietic stem cell transplant (HSCT) recipients the recognition of polymorphic antigens by the donor-derived immune system is an important mechanism underlying both graft-versus-host disease (GvHD) and graft-versus leukaemia (GvL) effect. Here we show that a subset of hematopoietic stem cell transplant recipients (13.9 %, n=108) have antibodies directed to surface molecules of dendritic...

BACKGROUND Distress can arise from physical and/or psychosocial impairments and has been documented in patients after hematopoietic stem cell transplantation in the outpatient setting. It has not been evaluated in inpatients admitted to undergo the transplant, nor has potential correlations with length of hospital stay, physical function, and pain after receiving the transplant. OBJECTIVES To...

Acute myeloid leukemia is a hematopoietic stem cell neoplastic disease associated with high morbidity and mortality. The presence of FLT3 internal tandem duplication mutations leads to high rates of relapse and decreased overall survival. Patients with FLT3 internal tandem duplication are normally treated with hematopoietic stem cell transplantation in first complete remission. Nevertheless, th...

Since the first successful allogenic hematopoietic stem cell transplant in 1972 by Dr. Thomas, the technique has gained importance worldwide. It has become potentially curative for many neoplastic and nonmalignant disorders. Hematopoietic stem cell transplantation (HSCT) using autologous or allogeneic hematopoietic progenitor cells has progressed and evolved because of the ability to apply new ...

An angioimmunoblastic T-cell lymphoma is a unique type of peripheral T-cell lymphoma; it has an aggressive course and a poor prognosis. There is no standard therapy for angioimmunoblastic T-cell lymphoma, especially for refractory or relapsed cases. Here, we report a case of 53-year-old woman with angioimmunoblastic T-cell lymphoma who underwent high-dose chemotherapy with an autologous hematop...