The first bone marrow transplantation took place in 1949 with studies that demonstrated the protection provided to the spleen of mice given a dose of irradiation that would otherwise be lethal. In 1960, studies in dogs provided important information about bone marrow transplantation in exogamic species, results that are applicable to humans. It was demon‐ strated that dogs could bear 2-3 times ...

The purpose of regenerative medicine [6], especially tissue engineering, is to replace damaged tissue with new tissue that will allow the body to resume normal function. The uniqueness of tissue engineering is that it can restore normal structure in addition to repairing tissue function, and is often accomplished using stem cells [7]. The first type of tissue engineering using stem cells [7] wa...

Although hematopoietic stem-cell transplantation was originally conceived more than 50 years ago as a treatment for injury from irradiation and, later, for cancer, associated problems needed to be solved before the procedure could be used clinically. Bone marrow, the source of hematopoietic stem cells, is not a solid organ but is rather diffuse and not directly accessible. Furthermore, hematolo...

Hematopoietic stem cell transplantation(HSCT), has been accepted as a feasible treatment option that prolongs survival in hematological malignancies. Stem cell choice during hematopoietic stem cell transplantation can differ according to the experience of physicians, mostly treated hematological diseases in the centers or ongoing clinical trials. In this chapter we will discuss the advantages a...

Hematopoietic stem cell transplantation was first reported for patients with systemic lupus erythematosus in 1997. The procedure has since been performed worldwide including in Europe, in Brazil, and in China. A National Institutes of Health-funded phase III clinical trial of hematopoietic stem cell transplantation for refractory systemic lupus erythematosus is anticipated to begin in 2003. Enc...

BACKGROUND Hematopoietic stem cell transplantation is a potential cure for a range of life-threatening diseases, but is also associated with a high mortality rate. Nurses encounter a variety of situations wherein they are faced with discussing bad news with hematopoietic stem cell transplantation patients. RESEARCH OBJECTIVE The aim of this study was to explore the experiences and strategies ...

The purpose of regenerative medicine [6], especially tissue engineering, is to replace damaged tissue with new tissue that will allow the body to resume normal function. The uniqueness of tissue engineering is that it can restore normal structure in addition to repairing tissue function, and is often accomplished using stem cells [7]. The first type of tissue engineering using stem cells [7] wa...

PURPOSE OF REVIEW To review the available clinical and biological advances of umbilical cord blood allogeneic stem cell transplantation in pediatric and adult patients. RECENT FINDINGS Recent large international studies suggested that allogeneic umbilical cord blood transplantation may potentially emerge as the frontline stem cell source for pediatric patients with hematopoietic malignancies ...

BACKGROUND Long-term outcome after hematopoietic stem cell transplantation including late transplant-related events is of increasing interest. The aim of this study was to evaluate the incidence of cardiovascular events after allogeneic HSCT and to search for their risk factors. DESIGN AND METHODS This is a retrospective multicenter European Group of Blood and Marrow Transplantation (EBMT) an...

Hematopoietic stem cell transplantation is a life-saving therapy in patients suffering from acute leukemia. However, kidney complications developed after performing hematopoietic can affect the course and prognosis of disease with This study aimed at assessing functional status kidneys leukemia who have undergone transplantation. The has observed group lymphoblastic myeloid It been discovered t...