Although Haemophilus influenzae requires heme for growth, the source of heme during invasive infections is not known. We compared heme, lactoperoxidase, catalase, cytochrome c, myoglobin, and hemoglobin as sources of heme for growth in defined media. The minimum concentration of heme permitting unrestricted growth of strain E1a, an H. influenzae type b isolate from cerebrospinal fluid, was 0.02...

Genetic mutations of the alpha genes are common worldwide. In Asia and particularly Southeast Asia, they can result in clinically significant types of alpha-thalassemia, namely hemoglobin (Hb) H disease and Hb Bart's hydrops fetalis. The latter is generally a fatal intrauterine condition, while Hb H disease results in clinical complications that are frequently overlooked. The high prevalence of...

background: children affected with sickle cell disease (scd) are at increased risk for severe morbidity and mortality, especially during the first 3-5 years of life. it is suggested that early treatment can improve the condition. the aim of this pilot study was to estimate the incidence of hemoglobin s (hbs) by umbilical cord blood screening in khorramshahr and abadan cities in southwest of ira...

Liposome encapsulated hemoglobin is being developed as an artificial resuscitative fluid for in vivo oxygen delivery. In the present report, we examine the effect of accumulation of liposome encapsulated hemoglobin on the structure of reticuloendothelial organs following administration of liposome encapsulated bovine hemoglobin in the normovolemic rat. We have also examined the administration o...

Plasmodium falciparum infecting hemoglobin (Hb)H and/or Hb Constant Spring erythrocytes has higher resistance to artemisinin in vitro than when infecting normal erythrocytes. This is due to low drug accumulation of infected erythrocytes resulting from competition with uninfected variant erythrocytes, which have a higher accumulation capacity than genetically normal cells. Drug accumulation of t...

IP Multicast is facing a slow take-off although it is a hotly debated topic since more than a decade. Many reasons are responsible for this status. Hence, the Internet is likely to be organized with both unicast and multicast enabled networks. Thus, it is of utmost importance to design protocols that allow the progressive deployment of the multicast service by supporting unicast clouds. This pa...

IP Multicast is a hotly debated topic since many years. F o r t h i s many reasons are responsible. Hence, the Internet is likely to be organized with both unicast and multicast enabled networks. Thus, it is of utmost importance to design protocols that allow the progressive deployment of the multicast service by supporting unicast clouds. This paper proposes HBH (Hop-ByHop multicast routing pr...

The variety of patients with thalassemia in Thailand offers an opportunity to fully characterize the kinetic causes of the anemia and to study apoptosis of marrow erythroid precursors as a possible factor contributing to its severity. Kinetic studies showed that in hemoglobin H (HbH) disease, the extent of hemolysis, as well as the minimally ineffective erythropoiesis, usually falls within the ...

T HE PLASMA PROTEINS of all but a small percentage of normal mdi-viduals possess the property of forming a complex with and of binding extracorpuscular hemoglobin. The capacity of these proteins, vhich have tentatively been identified as alpha-2-globulins,1 to bind hemoglobin is limited. Under in vitro and in vivo circumstances, hemoglobin may be bound in a concentration up to approximately 125...