Asymptomatic hemophilia patients receiving Factor VIII concentrate were found to have normal natural killer (NK) cells and B cells, and an inverted T helper/suppressor ratio due to an increase in cells of T suppressor phenotype. In contrast, a hemophilia patient with acquired immune deficiency syndrome (AIDS) exhibited nonfunctional NK cells, low B cells, and an inverted T helper/suppressor rat...

Hemophilia is a common hereditary coagulation blood disorder due to the deficiency activity of clotting factors. divided into two, namely hemophilia A and B. Among all treatments, standard half-life (SHL) extended (EHL) factor replacement products are most commonly used. This study aimed review real-world evidence on comparison SHL EHL. literature search was conducted in PubMed google scholar p...

Hemophilia B is a recessive bleeding disorder resulting from mutations in the coagulation factor IX gene. As this disease is characterized by clinical and molecular heterogeneity, the building of relationship between its genotype and phenotype would be great helpful for better diagnosis, prognosis and treatment. We use a descriptively probabilistic method, cross-impact analysis, to couple the c...

Background: Mothers and fathers mentioned difficulty in identifying the proper structure of remedy for their child, anxiousness about illness blood products, fear achievable long-term aspect consequences prophylaxis, a desire to avoid any unnecessary medications. It is clear from what has been noted above that mother appreciably want health care program help hemophilic young people limit compli...

OBJECTIVE The aim was to overview the oral health aspects in hemophilia patients. MATERIAL AND METHODS An electronic search of Medline (Pub Med), Cochrane, SSCI (Social Citation Index), SCI (Science Citation Index) databases from 1982 to the present, using the following search words: hemophilia, oral health, dental caries, dental caries prevalence, gingivitis, periodontitis, primary dentition...

Hemophilia is a hemorrhagic trend affects mostly males (X-related recessive disease). In 85% of cases it is caused by factor VIII deficiency, being called hemophilia A or classic hemophilia. In approximately 15% of cases there is factor IX deficiency (hemophilia B).[1-3] Hemophilia B is characterized into severe (<1%), moderate (1%–5%), or mild (5%–40%) phenotypes in light of the plasma compone...

Hepatitis C has a negative effect on health-related quality of life (HRQoL). It is not clear whether hepatitis C affects HRQoL of patients with hemophilia. The objective of this study was to assess the effect of hepatitis C virus (HCV) infection on HRQoL in patients with hemophilia. A cross-sectional study was performed among all registered hemophilia patients in the Netherlands. HRQoL was dete...

background:chronic synovitis is one of the most important complications in haemophilic patients. rifampin is anantibiotic which its intra-articular injecion leads to destruction of the synovial membrane of haemophilic patientsmedically.materials and methods: between september 2003 and november 2005, we administered intra-articular rifampinin ١۶ haemophilic joints of ٨ haemophilic patients.resul...

Dental health care workers are increasingly called upon to provide quality dental care to individuals whose bleeding and clotting mechanisms have been altered by inherited or acquired diseases. This provides an opportunity for the dentist who is trained in the recognition of oral and systemic signs of altered hemostasis to assist in the diagnosis of the underlying condition. A number of dental ...

Acquired hemophilia is a rare hemorrhagic disorder caused by the spontaneous appearance of inhibitory autoantibodies directed against endogenous coagulation factor VIII (FVIII). Inhibitory Abs also arise in patients with congenital hemophilia A as alloantibodies directed to therapeutic FVIII. Both autoimmune and alloimmune inhibitors neutralize FVIII by steric hindrance. We have described FVIII...