the present study was aimed to evaluate the beneficial effect of cystone syrup in an experimental model of glycerol-induced acute renal failure (arf) in rats. biochemical parameters, kidney weight and histopathological evaluation were performed to conclude the beneficial effect of cystone syrup. administration of single dose of 50% v/v glycerol (8ml/kg.i.m) caused severe renal dysfunction assoc...

BACKGROUND Lipopolysaccharide (LPS) preconditioning is known to attenuate hepatic ischemia/reperfusion injury (I/RI); however, the precise mechanism remains unclear. This study investigated the role of receptor-interacting protein 140 (RIP140) on the protective effect of LPS preconditioning in hepatic I/RI involving Kupffer cells (KCs). METHODS Sprague-Dawley rats underwent 70% hepatic ischem...

Abstract Background Erdheim-Chester disease (ECD) is a rare histiocytic disorder recently recognized as neoplasm due to the discovery of activating MAPK pathway mutations. Hepatic involvement by ECD extremely rare. Case presentation We describe case 64-year-old male who presented with pruritis, weight loss, and cholestatic liver function tests. Magnetic resonance imaging abdomen showed beaded a...

context patients with hepatic dysfunction suffer from many problems and associated complications in organs other than the liver. therefore, it is very important to investigate the effects of different drugs in the treatment of these patients. due to the high consumption of non-steroidal anti-inflammatory drugs (nsaids), studying the effects of these drugs in patients with hepatic dysfunction is...

Although there is a considerable interest of high-protein, low-carbohydrate diets to manage weight control, their safety is still the subject of considerable debate. They are suspected to be detrimental to the renal and hepatic functions, calcium balance, and insulin sensitivity. However, the long-term effects of a high-protein diet on a broad range of parameters have not been investigated. We ...

BACKGROUND Ethanolic extract of Euryale ferox salisb. (EFx) may have an effect on the activity of hepatic antioxidant enzymes, glycemic control and lipid profile and histopathology of pancreas, liver and kidney of streptozotocin (STZ)-induced diabetic wistar rats. METHODS Wistar albino rats were divided into eight groups viz. non-diabetic (normal control), diabetic control (STZ-induced), diab...

diabetes mellitus is the most common cause of chronic renal disorders and end-stage kidney disease in developed countries. it is the major cause of dialysis and transplantation. failure in renal function causes wide disorders in the body. diabetes results in wide range of alterations in the renal tissue. it is believed that early histological changes in diabetic nephropathy are detectable 2 yea...

Background: The idiopathic peptic ulcers (IPU), or non-Helicobacter pylori nonsteroidal anti-inflammatory drugs (NSAIDs)-associated ulcers, are a serious therapeutic challenge. prevalence of IPU is increasing in some parts the world. Objectives: This study aimed to determine southeastern Iran. Methods: In this cross-sectional study, total 367 patients with active ulcer were diagnosed by endosco...