Background: Cadmium (Cd) intoxication can cause oxidative stress and involve the antioxi-dant defense system in hepatocytes. Administration of vitamin C, chitosan, or a combination of both may prevent Cd-induced oxidative damage. Methods:Cyprinus carpio were distributed into six groups. The control group received normal feed (Group I). Group II was exposed to 0.2 mg.L-1 cadmium chloride. Gr...

Primary biliary cholangitis (PBC), formerly referred to as primary biliary cirrhosis, is an infrequent progressive intrahepatic cholestatic autoimmune illness that can evolve into hepatic fibrosis, hepatic cirrhosis, hepatic failure, and, in some cases, hepatocellular carcinoma. The disease itself is characterized by T-lymphocyte-mediated chronic non-suppurative destructive cholangitis and elev...

Moxifloxacin is a broad spectrum fluoroquinolone antibacterial agent. We examined the hepatic redox status and plasma biomarkers of nephrotoxicity and hepatotoxicity in rat following administration of moxifloxacin (MXF). Twenty-four Wistar rats, 180-200 g, were randomized into four groups (I-IV). Animals in group I (control) received 1 mL of distilled water, while animals in groups II, III, and...

The prevalence of nonalcoholic fatty liver disease (NAFLD) increases with increasing body mass index (BMI). However, approximately 40-50% of obese adults do not develop hepatic steatosis. The level of inflammatory biomarkers is higher in obese subjects with NAFLD compared to BMI-matched subjects without hepatic steatosis. We used a casein injection in high-fat diet (HFD)-fed C57BL/6J mice to in...

conclusions the mathematical meaning of the two insulin-related biomarkers examined was the same, and the odds ratios of the two biomarkers were almost the same after adjustments for other independent variables. objectives a one-year follow-up study was conducted to determine the ability of the insulin-related biomarkers to predict the risk of mets development. patients and methods a total of 2...

bladder cancer is the fifth most common cancer with significant morbidity and mortality. recently, numerous studies demonstrated that micrornas are emerging as diagnostic biomarkers for bladder cancer. specific mirna profiles have been identified for several samples from patients with bladder cancer. micrornas are noncoding rna molecules of approximately 23 nucleotides that play important roles...

abstract aim and background: studying the role of background causes and biomarkers on early onset cardiovascular diseases' incidence as one important issue is need for prevention of these diseases. the purpose of this study was to identify the role of background factors and biomarkers for early onset cardiovascular diseases' incidence. methods and materials: in a descriptive study with cross-se...

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Fabry disease is a lysosomal storage disease caused by a deficiency of alpha-galactosidase A, which results in aberrant glycosphingolipid metabolism and accumulation of globotriaosylceramide (Gb3). Since a correlation between the level of Gb3 and clinical manifestations of Fabry disease has not been observed, we investigated potential diagnostic biomarkers. Hepatic and renal gene expression of ...

Circulating microRNAs (miRNAs) can be employed as biomarkers to diagnose liver and other diseases. Noninvasive approaches are needed to complement and improve the current strategies for screening for biomarkers liver cirrhosis. We determined whether the serum levels of miRNAs can distinguish between chronic hepatitis B (CHB) and CHB-induced cirrhosis (HBC) and investigated the potential mechani...