BACKGROUND Hepatitis C is an infectious disease caused by blood-borne pathogen, hepatitis C virus (HCV). OBJECTIVES The purpose of this study was to investigate the prevalence of HCV infection and associated risk factors among addicts in drug treatment centers in Lorestan Province, Iran. PATIENTS AND METHODS A cross-sectional sero-behavioral survey was given to drug addicts in the drug trea...

CD4 T lymphocyte proliferative responses to hepatitis C virus (HCV) antigens were evaluated before and during an anti-HCV regimen (interferon-alpha2a and ribavirin) in 36 patients coinfected with HCV and human immunodeficiency virus (HIV), to determine whether immune responses against HCV antigens are present in such patients, whether these responses are modified by anti-HCV treatment, and whet...

Background and Aims: Recently, a novel DNA virus was isolated from the serum of a patient with post-transfusion non A-G hepatitis and named TT virus. The aim of this study was to determine the prevalence TT virus among cirrhotic patients due to hepatitis B & C in infection Ahwaz. Methods: The prevalence of TTV infection was studied in 41 patients with liver cirrhosis. TTV DNA was detected ...

A meta-analysis on the seroprevalence of hepatitis B surface antigen (HBsAg) and antibodies against hepatitis C virus (anti-HCV) in 27881 hepatocellular carcinomas from 90 studies confirmed wide international variations. A predominance of HBsAg was found in hepatocellular carcinomas from most Asian, African and Latin American countries, but anti-HCV predominated in Europe, North America, Japan,...

Although liver diseases are common in Bangladesh, the prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) has shown marked variation among studies and in different parts of this country.1-3 Rudra et al1 have shown that 126 of 2,015 subjects had HBV. On the contrary, Ashraf et al2 reported hepatitis B surface antigen (HBsAg) positivity at 0.7% individuals of Bangladesh. Mahtab et a...

Virus-specific cluster of differentiation 8 (CD8+) cytotoxic T cells (CTL) recognize viral antigens presented on major histocompatibility complex (MHC) class I chains on infected hepatocytes, with help from CD4+ T cells. However, this CTL response is frequently weak or undetectable in patients with chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infection. Programmed cell death 1 (P...

background: recently, some new viruses have been identified for their association with hepatitis which torque teno mini virus being among them. the aim of this study was to determine the frequency of torque teno mini virus in healthy individuals and hepatitis b and c patients in isfahan, iran. materials and methods: one hundred serum samples of healthy individuals from isfahan blood transfusion...

background: hepatitis b is an important infectious disease.  since several years ago, mass vaccination against this viral infection has become as part of routine vaccination schedule of iran.  however, some healthy neonates, children and adults fail to generate a protective antibody response after vaccination. objectives: to investigate distribution of hla class-i and class-ii antigens in healt...

BACKGROUND Nearly 20% of human cancers worldwide have an infectious etiology with the most prominent examples being hepatitis B and C virus-associated hepatocellular carcinoma and human papilloma virus-associated cervical cancer. There is an urgent need to find new approaches to treatment and prevention of virus-associated cancers. METHODOLOGY/PRINCIPAL FINDINGS Viral antigens have not been p...