Hepatocellular carcinoma is one of the main important causes of cancer-related death and its mortality is increasingly worldwide. In Europe, alcohol abuse accounts for approximately half of all liver cancer cases and it will become the leading cause of hepatocellular carcinoma in the next future with the sharp decline of chronic viral hepatitis. The pathophysiology of alcohol-induced carcinogen...

CONTEXT Liver cirrhosis patients with hepatocellular carcinoma present nutritional alterations and metabolic disorders that negatively impact the prognosis. OBJECTIVE The objective is to identify alterations in the metabolism of macro and micronutrients among liver cirrhosis patients with and without hepatocellular carcinoma and their relation to the Child-Turcote-Pugh score and Barcelona Cli...

Hepatocellular carcinoma usually afflicts individuals in their later years following longstanding liver disease. In Peru, hepatocellular carcinoma exists in a unique clinical presentation, which affects patients around age 25 with a normal, healthy liver. In order to deepen our understanding of the molecular processes ongoing in Peruvian liver tumors, mutation spectrum analysis was carried out ...

BACKGROUND In South America, the highest incidence of primary liver cancer is observed in Peru. However, national estimations on hepatocellular carcinoma incidence and mortality are approximated using aggregated data from surrounding countries. Thus, there is a lack of tangible information from Peru that impairs an accurate description of the local incidence, presentation, and outcomes of hepat...

Hepatocellular carcinoma (HCC) is one of the leading causes cancer-related death worldwide. Certain risks such as hepatotropic viruses like hepatitis C virus (HCV) and B (HBV), well alcohol usage nonalcoholic fatty liver disease (NAFLD) contribute to incidence HCC. Retrospective, observational study. Included patients diagnosed with HCC, demographic, clinicopathologic data, treatment strategies...

Cancer biomarkers have a remarkable role for not only early-stage detection of cancer but also in the monitoring therapy efficacy. Alpha-fetoprotein (AFP) is one which highly expressed hepatocellular carcinoma (HCC) patients. Therefore, high level AFP can be considered early diagnosis HCC. Electrochemical assays used as miniaturized biosensors real-time analytes are mostly categorized into thre...

Published incidences of hepatocellular carcinoma in the Black population of sub-Saharan Africa underestimate the true incidence of the tumor because of the many instances in which hepatocellular carcinoma is either not definitively diagnosed or is not recorded in a cancer registry. Despite this, it is manifestly evident that the tumor occurs commonly and is a major cause of cancer deaths in Bla...