Objective(s): MicroRNAs (miRNAs) are considered as powerful, post-transcriptional regulators of gene expression in hepatocellular carcinoma cells (HCC). However, the function of miR-92a is still unclear in HCC. Materials and Methods: Expression of miR-92a in human HCC cell lines was evaluated using qRT-PCR. MTT assay and transwell assay were used to examine the function of miR-92a in HepG2 and ...

Hepatocellular carcinoma (HCC) is the most common primary liver cancer and main cause of cancer-related death worldwide. The available treatment options for HCC include transplant, locoregional therapy (such as ablation, embolization, radiotherapy), systemic treatment. latter encompasses targeted therapy, immunotherapy, angiogenesis inhibitors, alone or in combination. introduction immune check...

Background: Besides their mutagenic, carcinogenic, and teratogenic effects, Aflatoxins (AFs) also act as the main contributor to hepatocellular carcinoma (HCC) which is known as the most common primary liver cancer worldwide. The main aim of this study was risk estimation of HCC due to exposure to aflatoxins in maize from Yogyakarta, Indonesia. Methods: As a model, maize samples were taken fro...

Abstract Background Hepatocellular carcinoma (HCC) is the most frequent primary invasive cancer of liver. During last decade, epidemiology HCC has been continuously changing in developed countries, due to more effective prevention and successful treatment virus-related liver diseases. The study aims examine survival by level access care patients with HCC, for all combined age. Methods We includ...

Abstract Background Early screening and intervention therapies are crucial to improve the prognosis of hepatocellular carcinoma (HCC) patients with bone metastasis. We aimed identify serum lncRNA as a prediction biomarker in HCC Methods The expression levels lnc34a samples from 157 were detected by quantitative real-time polymerase chain reaction (PCR). Univariate analysis multivariate performe...

Abstract Despite advances in treatment options for hepatocellular carcinoma (HCC), 5-year survival HCC remains below 20%. This poor is multifactorial but partly related to underuse of curative clinical practice. In light growing options, delivered by different types providers, optimal management requires input from multiple specialties. A multidisciplinary approach has been evolving over the pa...

conclusions the findings of this study reveal that both arg-1 and gpc-3 are helpful ihc markers to separate hcc from cc and ma. furthermore, arg-1 shows 100% sensitivity and 82.6% specificity for the diagnosis of hcc whereas gpc-3 demonstrated 97.7% sensitivity and 91.3% specificity for the diagnosis of this tumor. results arginase-1 and gpc-3 demonstrated diffuse staining, as reactivity in > 9...

BACKGROUND MiR-378 has been reported to be related to cell survival, tumor growth and angiogenesis and may participate in hepatocellular carcinoma (HCC) development and prognosis. Genetic variants in primary miR-378 (pri-miR-378) may impact miR-378 expression and contribute to HCC risk and survival. This study aimed to assess the associations between a genetic variant in primary miR-378 and HCC...

Background: Hepatocellular Carcinoma (HCC) is a major health problem worldwide and its diagnosis still challenging. Thioredoxin (TRX) class of small redox proteins known to be present in all organisms. It plays role many important biological processes, including signaling.
 Aims: The main aim this study was the serum thioredoxin level for assessment response after ablation therapy hepatoce...