Ochratoxin A (OTA) is a natural contaminant that has displayed nephrotoxicity and hepatotoxicity in mammals. It contaminates a great variety of foodstuffs and threatens people's lives. The molecular mechanism of OTA-induced toxicity has been studied since 1965. Moreover, epigenetic mechanisms are also studied in OTA-induced toxicity. Additionally, the mode of OTA epigenetic research has been ad...

Background: ocimum sanctum (Tulsi) “Queen of herbs” is considered as sacred and medicinal plant in a lot countries around the world especially India. Therefore this study was carried out to investigate heptorenal protective effect aqueous extract against gentamicin induced hepatorenal toxicity chickens.Materials Methods: A total 100, one-day old unsexed broiler chicks commercial breed (Cobb...

Cyclosporine toxicity mainly affects kidney and liver function. We have previously shown that cyclosporine nephrotoxicity alters kidney nitric oxide synthase mRNA pattern of expression. To determine if nitric oxide synthase expression changes are mediated directly by cyclosporine or by secondary hemodynamic alterations induced by cyclosporine, we evaluated if these effects are tissue specific a...

Citrinin is a kind of mycotoxin, which is produced during Monascus fermentation to produce Monascus Pigments. Studies have shown that citrinin has certain nephrotoxicity and hepatotoxicity, which can cause tumor, induce mutation and so on. The pretreatment of samples was carried out by ultrasonic assisted extraction centrifugal separation and nitrogen blowing concentration, and HPLC with fluore...

Glyphosate is a broad spectrum herbicide. Fruits and vegetables improve health and a diminish chronic degenerative processes. This study aims to investigate orange juice protective role against the toxicity of glyphosate induced in mice. Fifty six adult male albino mice divided into seven groups. Oral administration of glyphosate caused a significant increase in MDA levels, serum AST, ALT, BUN,...

This review analyzes current studies of the therapeutic effects of Phoenix dactylifera, or date palm fruit, on the physiologic system. Specifically, we sought to summarize the effects of its application in preventing cell damage, improving cancer therapeutics and reducing damage caused by conventional chemotherapy. Phoenix dactylifera exhibits potent anti-oxidative properties both in vitro and ...

Purpose: To investigate the effect of vomit seed homeopathic drugs (14CH and 30CH) on paracetamolinduced toxicity in rats.
 Methods: Thirty-two male Wistar rats were divided into 4 groups 8 animals each (n = 8) treated for 12 days. During treatment period, group (G) one (G1) which constitutes control received filtered water, whereas two (G2), three (G3), four (G4) gavaged with a toxic dose...

Objective. The aim of this study was to determine the protective effect p-coumaric acid (p-CA) against toluene-induced hepatotoxicity, nephrotoxicity and neurotoxicity in rats. Materials methods. A total 32 Sprague-Dawley male rats, 8 each group, were used. 4 groups formed as control, toluene, p-CA toluene+p-CA. Animals control toluene group given 0.9% NaCl, 0.9 mg/kg b.w 100 orally for 21 days...

Cisplatin (CP) is one of the most active cytotoxic agents in the treatment of cancer and has adverse side effects such as hepatotoxicity and nephrotoxicity. The aim of this study was focused on investigating the possible protective effect of royal jelly (RJ) against oxidative stress caused by CP injury of the liver and inflammatory changes in male albino rats. Twenty four albino rats were divid...

Ochratoxin A (OTA), mainly produced by Aspergillus and Penicillum species, is one of the most important mycotoxin contaminants in agricultural products. It is detrimental to human health because of its nephrotoxicity, hepatotoxicity, carcinogenicity, teratogenicity, and immunosuppression. OTA structurally consists of adihydrocoumarin moiety linked with l-phenylalanine via an amide bond. OTA bio...