P ATIENTS WITH LYMPHOMA, leukemia, multiple myeloma, or other conditions characterized by an altered immunologic state have an increased susceptibility to the manifestations of common viral infections. In such patients, disseminated infections with the DNA viruses, herpes simplex, and herpes zoster have carried a poor prognosis.1’2 Various attempts have been made to treat these disseminated inf...

abstract        background and objective: herpes simplex encephalitis is a life-threatening consequence of the central nervous system (cns) infection with herpes simplex virus (hsv). although it is a rare disease, mortality rates reach 70% in the absence of therapy and only a minority of individuals can return to normal function. the aim of this study was to determine possible correlation betwe...

background and objectives: encephalitis can cause a severe public health problem. the main aim of this research was to evaluate the medical laboratory results of patients with herpes simplex virus (hsv) encephalitis. materials and methods: diagnosis of encephalitis for these patients was firstly based on a clinical profile for herpes simplex encephalitis (hse), plus either a detected hsv1&2-dna...

background pcr is a molecular technique for herpes simplex virus (hsv) detection that can cause life-threatening infections such as encephalitis and keratitis. however, the main issues, false-negative results causing by pcr inhibitors, of this technique that reduce pcr efficiency. to overcome this problem, a competitive internal amplification control (iac) was constructed for conventional pcr u...

background: herpes simplex virus (hsv) is a member of herpesviridae and a leading cause of human viral diseases. meningitis occurs as a complication of hsv-1 or hsv-2 primary infection. objectives: we aimed to evaluate hsv meningitis in children in gorgan province, iran. patients and methods: forty-five cerebrospinal fluid samples were taken from children referred with meningitis symptoms. samp...

background patients with beta thalassemia suffer from increased susceptibility to infections and putridity plays a major role in the patient's morbidity and mortality. the risk of transfusion-transmitted viral infection is well known in these patients. however, there is dearth of information about the seroprevalence of herpes simplex virus (hsv) infection in patients with beta thalassemia in li...

PURPOSE To investigate whether passive transfer of antibodies to viral glycoproteins would protect against herpes simplex virus type 2-induced stromal keratitis. METHODS Balb/c mice were infected on the scarified cornea with herpes simplex virus types 1 or 2 (HSV-1 and HSV-2, respectively), and monoclonal or polyclonal antibodies were administered intraperitoneally 24 hr later. Eyes were moni...

The authors have investigated the course of herpes simplex type 1 (HSV) keratitis in three different inbred strains of mice infected with four different HSV isolates. Severity of ocular disease and mortality is dependent upon both the virus isolate and the host strain. In particular, the likelihood of progression from self-limited dendritic keratitis to severe necrotizing stromal keratitis vari...

acyclovir (9-[2-hydroxyethoxymethyl] guanine) is an acyclic nucleoside analogue of guanosine which is a potent and selective antiviral agent. acycloviris converted to the monophosphate by thymidine kinase the virus-specific form of this enzyme and is subsequently converted to the triphosphate by the host cell kinase. acyclovir triphosphate inhibits viral dna-polymerase terminating the chain and...

ulcerative colitis (uc) is one type of inflammatory bowel disease (ibd). herpes viruses have been suggested as possible etiological agents of uc and crohn’s disease (cd). the aim of this study was to investigate the prevalence of herpes simplex virus (hsv), cytomegalovirus (cmv) and epstein-barr virus (ebv) in patients with uc in comparison with healthy subjects by using pcr technique. in this ...