Herpetic encephalitis (HSE) is one of the most severe infection of the central nervous system (CNS), connected with high mortality rate, even when appropriate therapy has been introduced. Better understanding of pathomechanisms responsible for neuronal injury during the course of the disease can be useful in the assessment of the risk of the occurrence of severe complications, as well as in pot...

PURPOSE To report a case of acyclovir-resistant herpetic keratitis in a solid-organ lung transplant recipient that was effectively treated with topical trifluridine. METHODS A case of a 35-year-old female with herpetic epithelial keratitis resistant to acyclovir is described. The patient presented following treatment for 4 weeks with topical acyclovir ointment five times per day and oral vala...

BACKGROUND Between 1992 and 2001 the UK general practice incidence of post-herpetic neuralgia and trigeminal neuralgia declined, whilst the incidence of painful diabetic neuropathy increased. The most common first line treatments were compound analgesics. As therapeutic options have subsequently changed, this study presents updated data on incidence and prescribing patterns in neuropathic pain....

Background: Herpes simplex 1 co-infections in patients with COVID-19 are considered relatively uncommon; some reports on re-activations intensive-care units were published. The aim of the study was to analyze herpetic and their clinical manifestations hospitalized patients, performing HSV-1 PCR plasma twice a week. Methods: we conducted prospective, observational, single-center involving 70 con...

Objective Our objective was to characterize the patients with anti-NMDAR encephalitis and identify most common presenting symptoms etiologies. Background Anti N-methyl-d-aspartate receptor (NMDAR) is a specific autoimmune CNS disorder that decouples electrochemical synapses from their neuronal network, causing seizures, neuropsychiatric symptoms, movement problems, autonomic dysfunction. Althou...

Purpose : To discuss the definition and to determine the most logical intervention in treating patients with clinically foscamet resistant cytomgalovirus retinitis. Patients : Two patients with foscarnet clinically resistant cytomegalovims retinitis were followed in our department since june 1994. In these 2 patients, foscarnet was the first antiviral drug theraw civen for the treamxnt of cvtom...

Herpetic tracheobronchitis and pneumonia occur basically in immunodepressed patients, but have rarely been reported in patients with the acquired immunodeficiency syndrome (AIDS). Some large reviews on pulmonary manifestations in AIDS report a small number of herpetic pulmonary infections, without determining any prevalence of this particular viral involvement. Predisposing factors are alterati...

Autoimmune encephalitis is a difficult clinical diagnosis due to the similarities in the clini­cal, imaging and laboratory findings of many forms of autoimmune and infectious encephalitis. Autoimmune encephalitis involves several types: The first group includes the classic paraneo­plastic disorders associated with antibodies to intracellular antigens. The second group involves autoanti...