An efficient and convenient method to synthesize highly functionalized 3,7'-bisindole derivatives has been developed via a Michael addition and cyclic condensation reaction of heterocyclic ketene aminals (HKAs) with 2-(1H-indol-3-yl)cyclohexa-2,5-diene-1,4-dione derivatives in ethanol-based solvents at room temperature. This strategy provides an efficient, environmentally friendly approach for ...

The chemistry of metal cyclopropenyl complexes derived from deprotonation of cationic ruthenium vinylidene complexes is reviewed. Such a metal coordinated cyclopropenyl ligand can be used for the preparation of heterocyclic compounds. The chemical reactivity of cyclopropenyl complexes is influenced by the nature of substituents on the three-membered ring and by the nature of ancillary ligand ar...

A catalytic method has been developed for construction of indoline-2-thiones containing an all-carbon quaternary centre at the C-3 position. Successive treatment of α,β-unsaturated aldehydes bearing an isothiocyanato moiety with an in situ generated N-heterocyclic carbene and an appropriate heteroatomic nucleophile provided the 3,3-disubstituted indoline derivatives in moderate to good yields.

In search of bioactive molecules in the class of functionally substituted heterocyclic compounds, we synthesized some new N-(1-methyl-1H-pyrazole-4-carbonyl)thiourea derivatives and evaluated their analgesic and sedative effects. The obtained compounds were characterized by elemental analysis, IR and NMR spectroscopic analyses and evaluated for their analgesic and sedative effects.

Despite a significant work on 1, 2, 3-triazoles, continuous efforts are still being made to identify novel heterocyclic compounds with potent bioactivities. This review may help the medicinal chemists to develop new leads possessing 1, 2, 3-triazoles nucleus with higher efficacy. This review throws light on the detailed synthetic approaches which have been used for the synthesis of triazoles si...

Oxazolones are five membered heterocyclic compounds containing nitrogen and oxygen as hetero atoms. The C-2 and C-4 positions of the oxazolone are crucial for their various biological activities. N-substituted oxazolones also participated in variety of intermolecular reactions. Considering these properties, various research workers have shown a keen interest in this small heterocyclic moiety as...

Pyrazoles have been studied for over a century as an important class of heterocyclic compounds and continue to attract considerable interest due to the broad range of biological activities they possess. The incorporation of the essential structural features of pyrazoles with a ferrocene moiety could provide new derivatives with unexpected and/or enhanced biological activities since several ferr...

A DDQ-mediated domino reaction (up to six steps in a single process) has been developed to selectively provide substituted dihydrofurans from a common starting material containing a cyclic bis-thioenol ether. Study of the reaction mechanism highlighted a role played by the sulfur-containing moiety in influencing reaction rate and stereoselectivity.

Reactions of 1,3-propanediamine with alpha-dicarbonyl compounds (1a-e) were examined and various condensed heterocyclic compounds such as 1,4-diazepines (2) and 3-pyrimidine derivatives (3) were obtained. Some of 1,4-diazepines (2) showed DNA strand breakage activity.

A novel method for α-hydroxylation of ketones using substoichiometric amount of iodine under metal-free conditions is described. This method has been successfully employed in synthesizing a variety of heterocyclic compounds, which are useful precursors. α-Hydroxylation of diketones and triketones are illustrated. This strategy provides a novel, efficient, mild and inexpensive method for α-hydro...