نتایج جستجو برای: heterologous immunity
تعداد نتایج: 99989 فیلتر نتایج به سال:
UNLABELLED A putative biosynthetic gene cluster of the enterocin NKR-5-3B (Ent53B), a novel circular bacteriocin, was analyzed by sequencing the flanking regions around enkB, the Ent53B structural gene, using a fosmid library. A region approximately 9 kb in length was obtained, and the enkB1, enkB2, enkB3, and enkB4 genes, encoding putative biosynthetic proteins involved in the production, matu...
Previous studies of HIV-infected women with high-risk behavior have indicated that neither neutralizing antibody nor cellular immunity elicited by an initial HIV-1 infection is associated with protection against superinfection with a different HIV-1 strain. Here, we measured antibody-dependent cell-mediated virus inhibition (ADCVI) antibody activity in the plasma of 12 superinfected cases and 3...
The research was performed for the immunological characterization of the 37.81 kDa common immunodominant surface protein of some Salmonella serovars in order to examine the potency of that particular protein in terms of immunity production as well as withstood challenge exposure against virulent homologous and heterologous organism. The protective efficacy study in chicks gave protective levels...
The antigens of Yersinia ruckeri, Aeromonas salmonicida sp.salmonicida, Listonella anguillarum and Renibacterium salmoninarum were immunized to rainbow trout different ages immersion intraperitaneal, then waited 300 degree days, after which they infected with homologous heterologous strains the studied microorganisms. Prepared their various combinations used in experiments. After control infect...
Dendritic cells (DCs) are crucial for the priming of naive T and initiation adaptive immunity. Priming is initiated at a heterologous cell–cell contact, immunological synapse (IS). While it established that F-actin dynamics regulates signaling cell side little known about cytoskeletal contribution on DC side. Here, we show actin cytoskeleton decisive formation multifocal synaptic structure, whi...
Dengue viruses (DENV) are the most important mosquito transmitted viral pathogens infecting humans. DENV infection produces a spectrum of disease, most commonly causing a self-limiting flu-like illness known as dengue fever; yet with increased frequency, manifesting as life-threatening dengue hemorrhagic fever (DHF). Waning cross-protective immunity from any of the four dengue serotypes may enh...
African horse sickness virus (AHSV) belongs to the genus Orbivirus. We have now engineered naked DNAs and recombinant modified vaccinia virus Ankara (rMVA) expressing VP2 and NS1 proteins from AHSV-4. IFNAR((-/-)) mice inoculated with DNA/rMVA-VP2,-NS1 from AHSV-4 in an heterologous prime-boost vaccination strategy generated significant levels of neutralizing antibodies specific of AHSV-4. In a...
Live-attenuated influenza virus (LAIV) prime-boost vaccination previously conferred protection against heterologous H3N2 swine influenza challenge, including in piglets with maternally derived antibodies (MDA). Conversely, a whole-inactivated virus (WIV) vaccine was associated with enhanced disease. This study was aimed at identifying immune correlates of cross-protection. Piglets with and with...
Despite several efforts in the last decades, an efficacious HIV-1 vaccine is still not available. Different approaches have been evaluated, such as recombinant proteins, viral vectors, DNA vaccines, and, most recently, dendritic cell (DC) targeting. This strategy is based on DC features that place them as central for induction of immunity. Targeting is accomplished by the use of chimeric monocl...
We sought to test whether vaccine-induced immune responses could protect rhesus macaques (RMs) against upfront heterologous challenges with an R5 simian-human immunodeficiency virus, SHIV-2873Nip. This SHIV strain exhibits many properties of transmitted HIV-1, such as tier 2 phenotype (relatively difficult to neutralize), exclusive CCR5 tropism, and gradual disease progression in infected RMs. ...
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