We study linearised massive gravity on the de Sitter background. With a smallenough graviton mass this may have had relevance to inflation, or the present-day cosmic acceleration. Higuchi has shown that this theory has a ghost as long as the dS curvature exceeds the graviton mass, 2H2 > m2; this would entail rapid instabilities. In this work we extend the model and observe that the helicity-0 m...

The present research was designed to evaluate different matrix, drug-in-adhesive and reservoir formulations of fentanyl transdermal patches. The target was to design drug-in-adhesive patches (DIAPs); a full factorial design was used. Different types and amounts of liquid, pressure-sensitive adhesives (PSAs) were used and evaluated with respect to drug release and adhesive properties. A very sim...

The objective of the present research was to develop a bilayer tablet of propranolol hydrochloride using superdisintegrant sodium starch glycolate for the fast release layer and water immiscible polymers such as ethylcellulose, Eudragit RLPO and Eudragit RSPO for the sustaining layer. In vitro dissolution studies were carried out in a USP 24 apparatus I. The formulations gave an initial burst e...

The applicability of gallic acid loaded zein (Ze-GA) electrospun fibre mats towards potential active food packaging material was evaluated. The surface chemistry of the electrospun fibre mats was determined using X-ray photon spectroscopy (XPS). The electrospun fibre mats showed low water activity and whitish colour. Thermogravimetric analysis (TGA) and Attenuated Total Reflectance-Fourier Tran...

Perturbative gravity in global de Sitter space is subject to so-called linearization stability constraints: If they are to couple consistently to the gravitational field, quantum states must be invariant under the de Sitter isometries. While standard Fock spaces contain no de Sitter-invariant states apart from (possibly) the vacuum, a full Hilbert space of de Sitter-invariant quantum states can...

Transdermal drug delivery systems are polymeric patches containing dissolved or dispersed drugs that deliver therapeutic agents at a constant rate to the human body. Matrix type transdermal patches were prepared using alprazolam as a model drug and employing the combinations of chitosan-polyvinyl alcohol (CS-PVA) cross linked with Maleic anhydride. The transdermal patches were evaluated for the...

The present study was aimed to develop and evaluate nanoparticulate containing pioglitazone HCl as potential antidiabetic drug delivery system. The pioglitazone HCl -loaded chitosan nanoparticles were prepared by ionic gelation of chitosan with tripolyphosphate anions at various concentrations. The nanoparticles were characterized by zeta potential analyzer; particle size analyzer and Fourier t...

Prolonged release drug delivery system of stavudine was made by ionotropic gelation and polyelectrolyte complexation technique. Cross-linking reinforced chitosan-gellan complex beads were prepared by gelation of anionic gellan gum, the primary polymer, with oppositely charged counter ion to form beads which were further complexed with chitosan as a polyelectrolyte. The effect of this polymer on...

Metformin hydrochloride is an orally administered first line drug which commonly used in the management of type-2 diabetes. To overcome the side effects of it due to high/repeated dose and patient inconvenience, the sustained release microparticles of metformin loaded RS100 were developed. The method used to prepared microparticles was novel oil in oil technique. Obtained microparticles were ch...