In response to a 100-word footnote in the 1965 article by Monod, Wyman, and Changeux, a detailed manuscript signed by Francis Crick and Jeffries Wyman with 6000 words and 30 equations entitled "A Footnote on Allostery" circulated in 1965 among a limited group of scientists interested in allosteric interactions. This interesting and provocative document is published in this special issue for the...

We have examined the redox equilibria of azidomethemoglobin (low-spin) and fluoromethemoglobin (high-spin). We have derived a modified Hill equation which includes the tetramer--dimer equilibrium of the oxidized form, and also generalized the two-state model to incorporate ligand binding to the ferriheme. The pH dependence of the redox Hill's constant for fluoromethemoglobin is the same as that...

source arising from the viscous dissipation. This result has been noted by Lamb5 (p. 646). The error in equation (7) can thus be considered as arising from neglecting the heat produced by viscous dissipation of the kinetic energy. 1 Margules, M., Met. Z., 23, 481 (1906). 2 Bjerknes, V., and collaborators, Physikalische Hydrodynamik, Chap. 4, Julius Springer, Berlin, 1933. 3 Brunt, D., Physical ...