Abstract Histone deacetylases are important epigenetic regulators that have been reported to play essential roles in cancer stem cell functions and promising therapeutic targets many cancers including glioblastoma. However, the functionally relevant of specific histone deacetylases, maintenance key self-renewal growth characteristics brain tumour (BTSC) sub-populations glioblastoma, remain be f...

The c-Myc protein functions as a transcription factor to facilitate oncogenic transformation; however, the biochemical and genetic pathways leading to transformation remain undefined. We demonstrate here that the recently described c-Myc cofactor TRRAP recruits histone acetylase activity, which is catalyzed by the human GCN5 protein. Since c-Myc function is inhibited by recruitment of histone d...

The differentiation of hair (H) and non-hair (N) cells in the Arabidopsis thaliana root epidermis is dependent on positional relationships with underlying cortical cells. We previously found that histone acetylation relays positional information and that a mutant altered in the histone deacetylase gene family member HISTONE DEACETYLASE 18 (HDA18) exhibits altered H and N epidermal cell patterni...

Citation: Feng Y, Huang R, Guo F, Liang Y, Xiang J, Lei S, Shi M, Li L, Liu J, Feng Y, Ma L and Fu P (2018) Selective Histone Deacetylase 6 Inhibitor 23BB Alleviated Rhabdomyolysis-Induced Acute Kidney Injury by Regulating Endoplasmic Reticulum Stress and Apoptosis. Front. Pharmacol. 9:274. doi: 10.3389/fphar.2018.00274 Selective Histone Deacetylase 6 Inhibitor 23BB Alleviated Rhabdomyolysis-In...

The Molecules Editorial Office wishes to make the following erratum to this paper [1]. There is a misspelling in the title of “Antioxidant, Lipoxygenase and Histone Deacetylase Inhibitory Activities of Acridocarbus orientalis from Al Ain and Oman.” The correct title should be “Antioxidant, Lipoxygenase and Histone Deacetylase Inhibitory Activities of Acridocarpus orientalis from Al Ain and Oman...

Arabidopsis thaliana Histone Deacetylase 1 (AtHD1) and Epigenetic Regulation. (May 2004) Lu Tian, B.S., Fudan University, P.R.China Chair of Advisory Committee: Dr. Z. Jeffrey Chen Epigenetic regulation is a mechanism by which heritable changes in gene expression are controlled by chromatin status rather than primary DNA sequence. Changes in chromatin structure affect accessibility of DNA eleme...

One pharmacophore model and three quantitative structure-activity relationship models were developed on a series of benzimidazole and imidazole inhibitors of histone deacetylase 2. The goodness of hit score value of the best pharmacophore model was 0.756, which indicated that it is reliable to be used for virtual screening. The built pharmacophore model was used to search the NCI database. The ...

Members of the Mad family of bHLH-Zip proteins heterodimerize with Max to repress transcription in a sequence-specific manner. Transcriptional repression by Mad:Max heterodimers is mediated by ternary complex formation with either of the corepressors mSin3A or mSin3B. We report here that mSin3A is an in vivo component of large, heterogeneous multiprotein complexes and is tightly and specificall...

Human diploid fibroblasts (HDF) complete a limited number of cell divisions before entering a growth arrest state that is termed replicative senescence. Two histone deacetylase inhibitors, sodium butyrate and trichostatin A, dramatically reduce the HDF proliferative life span in a manner that is dependent on one or more cell doublings in the presence of these agents. Cells arrested and subseque...

Multiple myeloma is the second most common hematological malignancy. Despite all the progress made in treating multiple myeloma, it still remains an incurable disease. Patients are left with a median survival of 4-5 years. The combined treatment of multiple myeloma with histone deacetylase inhibitors and cytokine-induced killer cells provides a promising targeted treatment option for patients. ...