The cardiac natriuretic peptides atrial natriuretic factor (ANF) and brain natriuretic peptide (BNP) are discoordinately regulated in myocardial inflammation associated with acute allograft rejection in humans and during in vitro exposure of cardiocyte cultures to some proinflammatory cytokines. We used experimental autoimmune myocarditis (EAM) to determine whether the discoordinate regulation ...

We report a patient who presented with leg weakness and cervical lymphadenopathy. Thoracical magnetic resonance imaging showed an inhomogenously increased signal in the thickened portion of the cord. Multilevel laminectomy and spinal cord biopsy revealed granulomatous infiltrations with necrosis. Review of the histopathological finding established the diagnosis of necrotising sarcoid granulomat...

Poly-γ-glutamic acid (γ-PGA), naturally secreted from various strains of Bacillus, has anti-inflammatory activity. In inflammatory bowel disease (IBD), inflammation is promoted and sustained by angiogenesis; however, the role played by γ-PGA in this condition is unclear. Therefore, we evaluated γ-PGA effects on angiogenesis and inflammation in a dextran sulfate sodium-(DSS-) induced mouse colit...

BACKGROUND In the present study, we sought to evaluate the feasibility of targeting vascular adhesion protein-1 (VAP-1) by positron emission tomography (PET) for the longitudinal quantitative assessment of Borrelia burgdorferi infection-induced inflammation in mice. METHODS Mice with B. burgdorferi infection-induced arthritis were studied. During a 7-week follow-up period, the progression of ...

the toxic impact of copper sulfate in lethal and sublethal concentrations was investigated on gill of grass carp, ctenopharynogodon idella . in this investigation, 27 specimens were used as control group and three treatment groups were treated with 2.5 and 5mg/l of copper sulfate. gill samples were collected from each treatment after 96hr and lesions were analyzed by light microscopy. in histop...

Background: Tuberculosis infection of the Central Nervous System is major cause death and morbidity in developing countries. The clinical manifestations radiological findings tuberculoma are nonspecific. This article reports a rare case cerebellar with manifestation related to an intracranial mass without typical symptoms immunocompetent patient. Case Report: A 20-year-old female seizure, heada...

In chronic hepatitis, pathologies reveal a prominent inflammatory infiltrate portal consisting mostly of lymphocytes and plasma cells invading the portal spaces, although one can also identify macrophages, neutrophils or eosinophils. In all the forms of chronic hepatitis, fibrosis starts in the portal area, namely periportally, subsequently extends towards the lobules to the central veins, caus...

We report a four-year-old girl presented with progressive linear scleroderma affecting the right leg. Biopsy specimen disclosed typical histopathological findings of localized scleroderma. Right leg magnetic resonance image (MRI) showed high signal areas on T2 weighted images on the subcutaneous fatty tissue, muscles, and bone marrow, suggesting that skin inflammation extended to the bone marro...

Recent studies using magnetic resonance imaging have suggested that the subchondral bone marrow and the entheses are the sites which are primarily involved in the peripheral and axial inflammation found in patients with spondyloarthritides. Histopathological analyses indicated that the typical morphological features at these sites reflect an inflammation (osteitis) at the bone cartilage interfa...

tures of keratic precipitates during intraocular inflammation. To our knowledge, the use of IVCM to describe conjunctival pathological characteristics has not previously been reported. The human conjunctiva is an excellent tissue to examine using the confocal microscope because it is semitranslucent and the underlying vessels and cellular structures are easily accessible. The histopathological ...