Objective: Recent advances have contributed to a better understanding of the shared and specific roles HLA alleles in outcome Covid-19 disease. We aimed determine if severe prognosis could be predicted.

Certain HLA-B antigens have been associated with lack of progression to AIDS. HLA-B alleles can be divided into two mutually exclusive groups based on the expression of the molecular epitopes HLA-Bw4 and HLA-Bw6. Notably, in addition to its role in presenting viral peptides for immune recognition, the HLA-Bw4, but not HLA-Bw6, motif functions as a ligand for a natural killer cell inhibitory rec...

Natural killer (NK) cells kill normal and transformed hematopoietic cells that lack expression of major histocompatibility complex (MHC) class I antigens. Lysis of HLA-negative Epstein Barr virus-transformed B lymphoblastoid cell lines (B-LCL) by human NK cell clones can be inhibited by transfection of the target cells with certain HLA-A, -B, or -C alleles. NK cell clones established from an in...

A broad Gag-specific CD8(+) T-cell response is associated with effective control of adult human immunodeficiency virus (HIV) infection. The association of certain HLA class I molecules, such as HLA-B*57, -B*5801, and -B*8101, with immune control is linked to mutations within Gag epitopes presented by these alleles that allow HIV to evade the immune response but that also reduce viral replicativ...

Natural killer (NK) cells kill normal and transformed hematopoietic cells that lack expression of major histocompatibility complex (MHC) class I antigens. Lysis of HLA-negative Epstein Barr virus-transformed B lymphoblastoid call lines (B-LCL) by human NK cell clones can be inhibited by transfection of the target cells with certain HLA-A, -I3, or -C alleles. NK cell clones established from an i...

Ankylosing spondylitis (AS) is a common, highly heritable, inflammatory arthritis for which HLA-B*27 is the major genetic risk factor, although its role in the aetiology of AS remains elusive. To better understand the genetic basis of the MHC susceptibility loci, we genotyped 7,264 MHC SNPs in 22,647 AS cases and controls of European descent. We impute SNPs, classical HLA alleles and amino-acid...

Asthma is a complex and multifactorial disorder. Several studies have reported association between different HLA- DQB1 and HLA- DRB1 alleles and allergic asthma. The aim of the present study was to investigate the association of HLA-class II alleles and haplotypes, with total serum IgE and the results of the skin prick test in Iranian children with allergic asthma. A total of 112 patients with ...

Background Following the launch of global COVID-19 vaccination campaign, there have been increased reports autoimmune diseases developing de novo following vaccination. These cases include rheumatoid arthritis, hepatitis, immune thrombotic thrombocytopenia, and connective tissue diseases. Nevertheless, vaccines are considered safe for patients with strongly recommended. Objectives The aim this ...

Abstract Background : Suicide is a complex phenomenon determined by the interaction of various risk factors. The Major Histocompatibility Complex most polymorphic gene cluster entire human genome, being linked to both regulation immune system and psychiatric diseases. aim this study was identify HLA-DQB1 DRB1 alleles genotypes susceptible influence suicidal behavior. Methods We explored associa...

The HLA-DRB1 gene was reported to be associated with anticitrullinated protein/peptide autoantibody (ACPA) production in rheumatoid arthritis (RA) patients. A new classification of HLA-DRB1 alleles, reshaping the shared epitope (SE) hypothesis, was recently found relevant in terms of RA susceptibility and structural severity. We investigated the relevance of this new classification of HLA-DRB1 ...