Background First identified in 2001, human metapneumovirus (hMPV) is a novel pathogen and causative agent of acute respiratory tract infection. Re-infection with hMPV is common, and currently there is no available vaccine against this virus. Two genetic subgroups (A and B) have been identified, both of which can be divided further into at least two distinct sub-lineages. Here we report the resu...

A pan-virus DNA microarray (Virochip) was used to detect a human metapneumovirus (hMPV) strain associated with a critical respiratory tract infection in an elderly adult with chronic lymphocytic leukemia. This infection had previously eluded diagnosis despite extensive microbiological testing for possible etiologic agents. The patient's hMPV strain did not grow in viral culture, and only one of...

ObjectivesTo describe the prevalence, clinical features and complications of human metapneumovirus (hMPV) infections in a population adults hospitalized with influenza-like illness (ILI).MethodsThis was retrospective, observational, multicenter cohort study using prospectively collected data from adult patients during influenza virus circulation, for at least 24 h, community-acquired ILI (with ...

Recognition of infections with human metapneumovirus (HMPV) among institutionalised elderly is rising. When HMPV was found to be the causative agent of an outbreak of pneumonia in a residential care facility for elderly in the Netherlands, an elaborate outbreak investigation was set up, including active surveillance for new cases. From clinical cases, defined by fever (> 38°C) and symptoms of r...

Human metapneumovirus (hMPV) is a recently discovered pathogen associated with respiratory tract infections, primarily in young children, immunocompromised individuals, and elderly individuals. Reverse transcription-PCR (RT-PCR) has been reported to be a more sensitive method for the diagnosis of hMPV infections than virus isolation by culture and serological study. However, there has been no r...

BACKGROUND Limited information is available on the role of human metapneumovirus (HMPV) as the unique pathogen among children hospitalized for community-acquired pneumonia (CAP) in a tropical region. OBJECTIVE We aimed to describe HMPV infection among children with CAP investigating bacterial and viral co-infections. PATIENTS AND METHODS A prospective study was carried out in Salvador, Nort...

We investigated the proportions of mono vs. mixed infections for human metapneumovirus (hMPV) as compared to adenovirus (ADV), four types of coronavirus (CRV), parainfluenza virus (PIV), RSV, and enterovirus/rhinovirus (ERV) in Alberta, Canada. Using the Data Integration for Alberta Laboratories (DIAL) platform, 26,226 respiratory specimens at ProvLab between 1 July 2009 and 30 June 2012 were s...

Abstract Pneumoviruses such as the respiratory syncytial virus (hRSV) and human metapneumovirus (hMPV) are leading cause of acute lower tract infection, mainly in infants, elderly immunocompromised individuals, causing high morbidity mortality rates. However, these viruses can neurological alterations, encephalitis encephalopathy. Viral RNA pro-inflammatory molecules have been found patients wi...

We evaluated the percentage of hospitalizations for acute respiratory tract infections in children < or =3 years of age attributable to human metapneumovirus (HMPV) and other respiratory viruses in a prospective study during winter and spring 2002. We used real-time polymerase chain assays and other conventional diagnostic methods to detect HMPV, human respiratory syncytial virus (HRSV), and in...