Metagenomic next-generation sequencing (mNGS) is increasingly used for the unbiased detection of viruses, bacteria, fungi, and eukaryotic parasites in clinical samples. Whole-genome sequencing (WGS) of clinical bacterial isolates has been shown to inform hospital infection prevention practices, but this technology has not been utilized during potential respiratory virus outbreaks. Here, we repo...

background and objectives: the aim of the study was to determine the role and characteristics of nosocomial and community acquired staphylococcus sepsis in admitted children in tertiary centers in iran. patients and methods: a cross sectional descriptive-analytic study was performed since march 2008 to march 2009 in which all blood cultures from various admitted patients were checked for staphy...

ObjectivesTo describe the burden, epidemiology and outcomes of co-infections superinfections occurring in hospitalized patients with coronavirus disease 2019 (COVID-19).MethodsWe performed an observational cohort study all consecutive admitted for ≥48 hours to Hospital Clinic Barcelona COVID-19 (28 February 22 April 2020) who were discharged or dead. We demographic, epidemiologic, laboratory mi...

The incidence of community-associated, healthcare-associated, and hospital-acquired sterile-site infections due to methicillin-resistant Staphylococcus aureus (MRSA) isolates and the susceptibility of the isolates to non- beta -lactam antibiotics were evaluated for 549 hospitalized patients during a 3-year period. The incidence of community-associated MRSA infection increased significantly. The...

BACKGROUND Clostridium difficile is the major cause of nosocomial antibiotic-associated diarrhoea with the potential risk of progressing to severe clinical outcomes including death. It is not unusual for Clostridium difficile infection to progress to complications of toxic megacolon, bowel perforation and even Gram-negative sepsis following pathological changes in the intestinal mucosa. These c...

introduction liver abscess developing during hospital stay in pediatric patients on dialysis for acute kidney injury has been previously unreported. impaired immunity, prolonged use of antibiotics, diabetes and malnutrition predispose to liver abscess in chronic hemodialysis patients. case presentation we reported a case of liver abscess developing in a 6-year-old boy admitted with sepsis and m...

background legionellaceae contains legionella genus with over 52 species and 64 serogroups. it is one of the most important causes of respiratory disease in human. more than 30% of hospital-acquired pneumonia is caused by legionella. ventilator-associated pneumonia (vap) is an infection acquired in hospital wards, particularly in intensive care unit (icu). this disease approximately affects 9% ...

PURPOSE The objective of this study was to compare epidemiology, causative pathogens, outcome, and levels of laboratory markers of inflammation of community-onset (i.e. community-acquired and healthcare-associated) and hospital-acquired bloodstream infection (BSI) in South-East Austria. METHODS In this prospective cohort study, 672 patients fulfilling criteria of systemic inflammatory respons...