A novel bioresponsive controlled-release biosensor using Au nanocages capped with an aptamer-based molecular gate was reported for the first time. The use of aptamers as caps has proven to be a suitable method for the preparation of "bio-gated" delivery systems that can be selectively opened in the presence of target biomolecules.

objective(s):estrogen (e2) has neuroprotective effects on blood-brain-barrier (bbb) after traumatic brain injury (tbi). in order to investigate the roles of estrogen receptors (ers) in these effects, er-α antagonist (mpp) and, er-β antagonist (phtpp), or non-selective estrogen receptors antagonist (ici 182780) were administered. materials and methods: ovariectomized rats were divided into 10 gr...

case features are assigned configurationally to the Th-roles in a predicate’s Semantic Form. They cannot be idiosyncratic lexical properties of specific Th-roles, and their assignment cannot be specific to particular predicates. This means that the abstract Case feature [+HR] always defines the highest syntactically visible Th-role of a predicate, its “subject”. Given the previously introduced ...

Homologous recombination (HR) initiates double-strand break (DSB) repair by digesting 5'-termini at DSBs, the biochemical reaction called DSB resection, during which DSBs are processed by nucleases to generate 3' single-strand DNA. Rad51 recombinase polymerizes along resected DNA, and the resulting Rad51-DNA complex undergoes homology search. Although DSB resection by the Mre11 nuclease plays a...

Although strategic human resource (HR) management research has established a significant relationship between high-performance HR practices and firm-level financial and market outcomes, few studies have considered the important role of employees’ perceptions of HR practice use or examined the more proximal outcomes of high-performance HR practices that may play mediating roles in the HR practic...