An analysis of the chromosomal karyotype of the human promyelocytic HL-60 leukemia cell line and of a number of its sublines that exhibit varying degrees of resistance to induction of differentiation by phorbol-12-myristate-13-acetate was con ducted. The HL-60 cell line and the derived sublines contained two consistent marker chromosomes [9pand t(10;13)], which suggested that they have a common...

In the classic model of the heat shock response (HSR), the presence of denatured proteins triggers the expression of heat shock proteins (HSPs) via heat shock transcription factors (reviewed in Voellmy and Boellmann, 2007). Many HSPs are molecular chaperones that bind misfolded proteins. However, this model has increasingly been seen as inadequate to explain the entirety of HSRs (e.g., Kotak, e...

Abstract Wheat is one of the major allergenic foods capable eliciting life-threatening anaphylaxis. Discovering potential hypo/hyper-allergenic wheat classes imperative to advance our knowledge and manage allergy. Durum (genome AABB) soft white AABBDD) are two commonly consumed wheats. However, whether there differences in intrinsic allergenicity between them unknown. Here, we tested hypothesis...

BACKGROUND Nevirapine (NVP) is often prescribed once daily in clinical practice in combination with a once daily nucleoside backbone. We investigated the relationship of NVP dosing with safety and efficacy. METHODS Patients from the Dutch AIDS Therapy Evaluation in the Netherlands (ATHENA) cohort study, Canadian HAART Observational Medical Evaluation and Research (HOMER) cohort and Swiss HIV ...

Metropolitan areas shoulder the crucial task of regional and even national economic development. Analyzing spatial patterns influencing factors metropolitan traffic dominance can provide a scientific basis for optimization its transportation industrial layout, which is conducive to development economy. Previous studies on paid little attention less so study these from perspective town units, th...

BACKGROUND We aimed to assess the value of a structured clinical assessment and genetic testing for refining the diagnosis of abacavir hypersensitivity reactions (ABC-HSRs) in a routine clinical setting. METHODS We performed a diagnostic reassessment using a structured patient chart review in individuals who had stopped ABC because of suspected HSR. Two HIV physicians blinded to the human leu...

Copyright © 2007 by the International Association for the Study of Lung Cancer S466 Materials and Methods: Enrollees received Cb AUC 6 day 1 in combination with Pac 100 mg/m2 days 1, 8, and 15 every 4 weeks, and C225 at a loading dose of 400 mg/m2 day 1, then 250 mg/m2 weekly thereafter. C225 was continued as a single agent after 6 full cycles of therapy in patients without disease progression ...

Molecular cloning of genomic sequences altered in cancer cells is believed to lead to the identification of new genes involved in the initiation and progression of the malignant phenotype. DNA amplification is a frequent molecular alteration in tumor cells, and is a mode of proto-oncogene activation. The cytologic manifestation of this phenomenon is the appearance of chromosomal homogeneously s...

Maintenance of a sustainable clean water supply is critical for our future. However, watershed degradation is a common phenomenon around the world that leads to poor water quality. In order to protect water resources, the Watershed Forest Management Information System (WFMIS), was developed as an extension of ArcGIS and is described in this paper. There are three submodels to address nonpoint s...

Oestrogen receptor-alpha (ERα), encoded by the ESR1 gene located on 6q25, is a nuclear transcription factor. Since it was reported in 2007 that more than 20% of breast cancers show ESR1 gene amplification, there has been considerable controversy about its frequency and clinical significance. We set out to assess the frequency and levels of ESR1 amplification in breast cancers. In a total of 106...