The rapid regenerative response of the rat liver to partial hepatectomy is associated with a decline in liver epidermal growth factor receptor numbers which implies that ligand epidermal growth factor receptor interactions maybe important in initiating and/or modulating this process. The proliferative process in toxic hepatitis (where in contrast with partial hepatectomy the majority of hepatoc...

Abbreviations: BRET, bioluminescence resonance energy transfer; EGFR, epidermal growth factor receptor; ER, endoplasmic reticulum; ERC, endocytic recycling compartment; FRET, fluorescence resonance energy transfer; GFP, green fluorescent protein; HEK, human embryonic kidney; IR, insulin receptor; MEF, mouse embryonic fibroblast; pNPP, p-nitrophenylphosphate; PDGFR, platelet derived growth facto...

PI3K: Phosphoinositide 3-Kinase; Akt or PKB: Protein Kinase B; cAMP: Cyclic Adenosine Monophosphate; ATP: Adenosine Triphosphate; NFκB: Nuclear Factor Kappa B; APC: Adenomatous Polyposis Coli; GEO: Gene Expression Omnibus; GI: Gastrointestinal; EGFR: Epidermal Growth Factor Receptor; HER2: Human Epidermal Growth Factor Receptor 2; AURKA: Aurora kinase A; IP3: Inositol Triphosphate; PLC: Phospho...

Metastatic hormone receptor-positive (HR+) human epidermal growth factor receptor 2-negative (HER2-) breast cancer survival outcomes have improved significantly; however, once endocrine resistance develops, response rates to systemic treatments are limited. Within the developing field of antibody–drug conjugates, TROPiCS-02 study showed a significant improvement in progression-free with sacituz...