Human herpesvirus 8 (HHV-8) associated primary eVusion lymphomas arise and grow in the body cavities as eVusions, but it is not known whether the lining of body cavities and mesothelium derived malignancies are potential targets of HHV-8 infection. We examined a series of 13 diVuse malignant mesotheliomas and four mesothelial cell rich eVusion samples of non-neoplastic aetiology from nonimmunod...

Kaposi's sarcoma occurs at high incidence among Zambian adults and children, but there is a paucity of data on human herpesvirus 8 (HHV-8) incidence and routes of infection, especially in children. Between 1998 and 2004, the authors conducted a prospective study of viral transmission in a cohort of 684 children in Lusaka, Zambia, to estimate the annual incidence of HHV-8 from birth through 48 m...

Human herpesvirus 8 (HHV-8) can be classified into distinct subtypes on the basis of sequence polymorphisms in several open reading frames (ORFs). We analyzed the subtypes of HHV-8 in 59 human immunodeficiency virus-infected Japanese patients by using polymorphisms in ORF26 and found that over two-thirds of the HHV-8 isolates fell into major subtype A. We also found that single nucleotide polym...

The association of mycosis fungoides and kaposi's sarcoma in HIV-negative patients is a rare phenomenon. The presence of human herpesvirus 8 (HHV-8) - associated with all forms of Kaposi's sarcoma - has also been recently identified in mycosis fungoides lesions. However, a causal association between HHV-8 and the onset of mycosis fungoides has not been established yet. The present case reports ...

Human herpesvirus 8 (HHV-8), or Kaposi's sarcoma-associated herpesvirus, is a gammaherpesvirus first detected in Kaposi's sarcoma tumor cells and subsequently in primary effusion lymphoma (PEL) tumor cells and peripheral blood mononuclear cells from PEL patients. PEL has been recognized as an individual nosologic entity based on its distinctive features and consistent association with HHV-8 inf...

The specific route and timing of human herpesvirus (HHV) 8 infection in regions where Kaposi sarcoma is endemic are not known. HHV-8 infection and any risk factors that may be associated with HHV-8, including human immunodeficiency virus (HIV) type 1 infection, were monitored during the 12-month postdelivery period for 416 mothers and 485 infants from Lusaka, Zambia. HHV-8 incident infection ra...

Multicentric Castleman disease (MCD) is a lymphoproliferativedisorderassociatedwith human herpesvirus 8 (HHV-8) infection among persons with human immunodeficiency virus (HIV) infection. Treatment often includes chemotherapy, and progression to non-Hodgkin lymphoma frequently occurs. MCD is characterized in part by active HHV-8 replication, and many of the symptoms of MCD may be attributable to...

RF: HHV-8 and multiple myeloma in the UK. Lancet 350:1144, 1997 (letter) 7. Gao S-J, Alsina M, Deng J-H, Harrison CR, Montalvo EA, Leach CT, Roodman GD, Jenson HB: Antibodies to Kaposi’s sarcomaassociated herpesvirus (human herpesvirus 8) in patients with multiple myeloma. J Infect Dis 178:846, 1998 8. Basten A, Brink R, Peake P, Adams E, Crosbie J, Hartley S, Goodnow CC: Self tolerance in the ...

RF: HHV-8 and multiple myeloma in the UK. Lancet 350:1144, 1997 (letter) 7. Gao S-J, Alsina M, Deng J-H, Harrison CR, Montalvo EA, Leach CT, Roodman GD, Jenson HB: Antibodies to Kaposi’s sarcomaassociated herpesvirus (human herpesvirus 8) in patients with multiple myeloma. J Infect Dis 178:846, 1998 8. Basten A, Brink R, Peake P, Adams E, Crosbie J, Hartley S, Goodnow CC: Self tolerance in the ...

associated herpesvirus infection and multiple myeloma. Science 278: 1972, 1997 4. Rettig M, Vescio R, Ma H, Schiller G, Savage A, Berenson J: Sequence variability of HHV-8 from the dendritic cells of multiple myeloma patients. Blood 90:86a, 1997 (suppl 1) 5. Cathomas G, McGandy CE, Terracciano LM, Itin PH, De Rosa G, Gudat F: Detection of herpesvirus-like DNA by nested PCR on archival skin biop...