Abstract Activation of CD8 +T cells against pathogens and cancers involves the recognition antigenic peptides presented in complex with human leukocyte antigen (HLA) class-I proteins. Peptide binding to HLA-I proteins is coordinated by a multi-protein called peptide loading (PLC). Tapasin, key PLC component, facilitates optimization peptides. However, different allotypes have variable requireme...

To the Editor: The review on the importance of the major histocompatibility complex (MHC) in infectious diseases by Singh et al. (Emerg Infect Dis 1997;3:41-9) failed to mention the potential role of human leukocyte antigen (HLA)-DM in conferring susceptibility to infectious diseases. HLA-DM is an MHC class II-like molecule essential for normal antigen processing and presentation (1). HLA-DM ha...

objective: hla-g is a nonclassical major histocompatibility complex antigen and is expressed as seven isoforms, including four membrane bound (hla-g1 to –g4) and three soluble (hla-g5 to –g7) forms. the pattern of selective expression of hla-g transcripts in tissues shows the existence of a tight transcriptional control on the gene expression. it has been revealed that cytokines including inter...

background: pediatric bronchial asthma is associated with considerable morbidity. the study was carried out to examine the association of human leukocyte antigen (hla)- class ii with the disease as we found no similar study on asian indian population. objective: to define the hla-class ii antigens in asian indian pediatric patients with asthma. methods: a total of 103 children with asthma and 1...

Inherited susceptibility to rheumatoid arthritis (RA) is associated with the DRB1 genes encoding the human leukocyte antigen (HLA)-DR4 and HLA-DR1 molecules. Transgenic mice expressing these major histocompatibility complex (MHC) class II molecules have been developed to generate humanized models for RA. The relevance of these models for understanding RA will be discussed.

Recently developed computational methods allow the imputation of human leukocyte antigen (HLA) genes using intergenic single nucleotide polymorphism markers. To improve the imputation accuracy in HLA imputation, it is essential to increase the sample size and the diversity of alleles in the reference panel. Our software, MergeReference, helps achieve this goal by providing a streamlined pipelin...

background: natural killer (nk) cells are the effector cells of innate immunity that respond to infection and tumor. interactions between killer cell immunoglobulin like receptors (kir) and human leukocyte antigen (hla) class i molecules regulate nk cells responses to eliminate infected and transformed cells. objective: to investigate the impact of kir genes, hla ligand genes, and kir-hla combi...

introduction: the major histocompatibility complex (mhc) is a group of cell surface proteins that are essential for recognizing foreign molecules in human and other mammals. the physiologic function of mhc molecules is the presentation of peptides to t cells. in this study, we evaluated the purification of a class ii mhc molecule (hla-dr) from a human burkitt′s lymphoma cell line; daudi. materi...

background: the human leukocyte antigen (hla) matching between organ donor and recipient is an acceptable strategy in clinical transplantation since 1964. however, in bone marrow transplantation, finding matched donors is often problematic. thus new method for down regulation of hla can be an alternative strategy to solve this problem. objective: to examine the effect of serum starvation on hla...