background: due to increasing clinical demand for adipose tissue, a suitable cell for reconstructive adipose tissue constructs is needed. in this study, we investigated the ability of human endometrial-derived stem cells (enscs) as a new source of mesenchymal stem cells to differentiate into adipocytes. enscs are the abundant and easy available source with no immunological response, for cell re...

background chronic allograft nephropathy(can)  is one of the most common causes of chronic and end stage renal disease. it  is defined with mainly tubular atrophy and  interstitial fibrosis and no evidence of any other etiology, or functional disorder that caused at least three months after transplantation . control of risk factors (htn,dm,hlp, …) and limiting  usage of calcineurin inhibitors o...

Objective(s) The use of co-culture cells as well as extra cellular matrix are among those strategies that have been employed to direct mesenchymal stem cell (MSC) bone differentiation in culture. In this regard, there is no study considering the effects of Matrigel on mesenchymal stem cell (MSC) in vitro bone differentiation. This was the subject of the present study. Materials and Methods ...

background: mesenchymal stem cells (msc) have ability to regulate immune response via proinflamatory cytokines. in this study we aimed to investigate the effect of different mechanism for t cell activation and adjacency on immunoregulatory properties of msc. methods: bone marrow mscs were purchased and t cells were obtained from whole blood sample. t cells were activated by two different mechan...

objective(s): stem cell therapy is believed to be as a promising treatment strategy for tissue repair and regeneration. the plasticity specification of the adult stem cells, such as mscs, has enabled that these cells to be used in the treatment of a broad spectrum of diseases like liver disorders. in this study, the production of urea and albumin (alb), glycogen storage, and expression of some ...

objective(s): the main characteristic of mesenchymal stem cells (mscs) is their ability to produce other cell types. electromagnetic field (emf) stimulates differentiation of mscs into other cells. in this study, we investigated whether emf can effect on the differentiation of mscs into dopaminergic (da) neurons. materials and methods: an emf with a frequency of 50 hz and two intensities of 40 ...

objective(s) mesenchymal stem cells (mscs) are nonhematopoietic stromal cells that are capable of differentiating into and contribute to the regeneration of mesenchymal tissues. human mesenchymal stem cells (hmscs) are ideal targets in cell transplantation and tissue engineering. enhanced green fluorescent protein (egfp) has been an important reporter gene for gene therapy. the aim of this stud...

background: adipose-derived stem cells (adsc) could be an appealing alternative to bone marrow stem cells (bmsc) for engineering cell-based osteoinductive grafts. meanwhile, prior studies have demonstrated that melatonin can stimulate osteogenic differentiation. therefore, we assayed and compared the melatonin effect on osteogenic differentiation of bmsc with that of adsc. methods: mesenchymal ...

introduction: in this study, the effect of para-nonylphenol as an environmental pollutant on viability, morphology and proliferation of bone marrow mesenchymal stem cells was investigated. methods: bone marrow mesenchymal stem cells of rat were treated with the 0.5, 1, 2.5, 3.5 and 5 μm of paranonylphenol for a period of 21 days, then the viability of the cells were estimated using trypan blue ...

conclusions based on our findings, we conclude that the separation and reproduction of adipose tissue cells is an appropriate method for purification of mscs in animal studies. regarding the histomorphometric and flow cytometry analysis results, we demonstrated the differentiation ability of mscs in normal medium and hope to employ these cells for the regeneration of damaged bone tissues in the...