PURPOSE To evaluate the merit of umbilical artery Doppler study as a predictive marker of perinatal outcome in preterm small for gestational age (SGA) infants. MATERIALS AND METHODS A total of 218 patients at 27 - 36 weeks of gestational age (GA) who received antenatal umbilical artery Doppler velocimetry and delivered singleton infants with SGA. The ratio of peak-systolic to end-diastolic bl...

In fetal sheep, umbilical responsiveness to ANG II exceeds systemic vascular responsiveness. Fetal systemic vascular smooth muscle (VSM) exhibits an immature phenotype with decreased contractile protein contents, low 200-kDa myosin heavy chain (MHC) SM2, and significant nonmuscle MHC-B expression, whereas umbilical VSM phenotype is incompletely described. We tested the hypothesis that differenc...

Background: In this study, we examined a new two step induction protocol for improving the differentiation of human umbilical cord blood-derived mesenchymal stem cells into neural progenitor cells. Materials and Methods: Human umbilical cord blood-derived mesenchymal stem cells were first cultured in Dulbecco’s modified eagle medium supplemented with 10% fetal bovine serum in a humidified incu...

The objective was Ephedrine, Mephentermine, and Phenylephrine was compared in the treatment of maternal hypotension following spinal anesthesia for elective cesarean delivery. The Design was Randomized, double-blind trial and Setting in Obstetric suite at a university-affiliated hospital. The Patients were sixty healthy patients electively scheduled for cesarean delivery under spinal anesthesia...

Umbilical artery catheters have been associated with thrombotic complications, such as partial or complete occlusion in the aorta, the renal arteries, and other blood vessels. There have been few reports of the long-term consequences of either symptomatic or asymptomatic thrombi. We report a patient, now 22 years of age, born with a normal aorta, who developed hypertension at the age of 2 month...

INTRODUCTION Basilar artery dissection is a rare occurrence, and is significantly associated with morbidity and mortality. To the best of our knowledge, we report the first case of basilar artery dissection treated with mesenchymal stem cells. CASE PRESENTATION We present the case of a 17-year-old Korean man who was diagnosed with basilar artery dissection. Infarction of the bilateral pons, m...

OBJECTIVE The aim of this study was to examine the possible association between umbilical artery pulsatility index (PI) at 10-14 weeks of gestation and either increased fetal nuchal translucency (NT) or fetal chromosomal abnormality. DESIGN This was a prospective study of women undergoing chorionic villus sampling (CVS). SUBJECTS A total of 458 women undergoing CVS were studied; in 418 case...

OBJECTIVE To compare umbilical and middle cerebral artery Doppler ultrasound values in high and low risk pregnancies withfoetal outcome. DESIGN Descriptive prospective study. SETTING Aga Khan University Hospital, Nairobi between the months of February and November 2007. SUBJECTS One hundread and twenty one consecutive female subjects, between 24 and 443 years of age, at or over 28 weeks g...

AIM To study the role of Doppler imaging in prediction of high-risk pregnancies and their outcomes. METHODS AND MATERIAL This prospective study in a setup of tertiary-level care center includes 500 high-risk pregnant women from rural and urban sectors and evaluates the predictive values of various Doppler indices. RESULTS Out of 500 patients, 110 patients had abnormal Doppler among them, 70...