We develop a new method for describing patient characteristics associated with extreme good or poor outcome. We address the problem with a regression model composed of extrema (maximum and minimum) functions of the predictor variables. This class of models allows for simple regression function inversion and results in level sets of the regression function which can be expressed as interpretable...

High-resolution seismic reflections were used to map the upper 200 m along an approximately 22 km stretch of U.S. 50 highway in Reno County, Kansas, where natural and anthropogenic salt dissolution is known to threaten ground stability. Surface subsidence in this part of Kansas can range from gradual (an inch per year) to catastrophic (tens of feet per second), representing a significant risk t...

Two Iranian cases with very rare progeroid syndrome are reported. The first is a 24-year-old girl who has been healthy till her 13th birthday. From that time she has been suffering from a progressive generalized and multi-systemic illness. The cardinal clinical findings were growth retardation, subcutaneous fat loss, skin dryness and wrinkling, scattered focal sclerodermoid-like changes, promin...

Abstract Until comparatively recently, Lucy Hutchinson’s Memoirs were read as a personal and private document, and, even though their significance primary historical source is now increasingly recognized, it still generally assumed that they conceived solely for circulation within her own family. Their true business, however, with public affairs posterity. Like the many other late seventeenth-c...

Progeria, also known as the Hutchinson-Gilford syndrome, is an extremely rare condition that was initially reported by Jonathan Hutchinson in 1886 and further described by Hastings Gilford in 1904. Hutchinson Gilford progeria syndrome is a disorder characterized by premature aging of postnatal onset. The main clinical and radiological features include alopecia, thin skin hypoplasia of nails, lo...

Hutchinson– Gilford Progeria Syndrome is a very rare disorder characterized by premature ageing caused due to mutation in LMNA gene. The child born with this disorder shows features of old age from first year of birth and generally dies in teenage. The clinical symptoms include alopecia, thin skin, stiffness of joints etc. All of the children suffering from this disease appear identical. The pa...

The aim of the present paper is to extend classical fractal theory using condensing maps and generalized contractions semimetric spaces. Our method independent from approach Hutchinson: It based on Kuratowski measure noncompactness avoids completely Blaschke Completeness Theorem.