Candida albicans is the most common human fungal pathogen and has a high propensity to develop biofilms that are resistant to traditional antifungal agents. In this study, we investigated the effect of tetrandrine (TET) on growth, biofilm formation and yeast-to-hypha transition of C. albicans. We characterized the inhibitory effect of TET on hyphal growth and addressed its possible mechanism of...

Beta-1,2-linked mannosides (beta-Mans) are believed to contribute to Candida albicans virulence. The presence of beta-Mans has been chemically established for two molecules (phosphopeptidomannan [PPM] and phospholipomannan) that are noncovalently linked to the cell wall, where they correspond to specific epitopes. However, a large number of cell wall mannoproteins (CWMPs) also express beta-Man ...

BACKGROUND Vulvovaginal candidiasis (VVC) is a common gynecological disease. Candida albicans is believed to be mainly implicated in VVC occurrence, the biofilm of which is one of the virulence factors responsible for resistance to traditional antifungal agents especially to fluconazole (FCZ). Quercetin (QCT) is a dietary flavonoid and has been demonstrated to be antifungal against C. albicans ...

lentinan a polysaccharide from medicinal mushroom i.e lentinus, has been known to have anticancer properties. telomerase activity is not observed in normal healthy cells, whereas in cancerous cells telomerase expression is high. telomerase represents a promising cancer therapeutic target. we investigated the inhibitory effect of lentinan on telomerase reverse transcriptase gene (htert) which is...

lentiviral vectors are promising gene delivery tools capable of transducing a variety of dividing and non-dividing cells, including pluripotent stem cells which are refractory for transduction by murine retroviruses. although there is a growing debate on the safety of lentiviral vectors for gene transfer, in particular for those derived from human immunodeficiency viruses, type one (hiv-1) and ...

abstract background: schizophrenia is a severe mental disorder and numerous genes and loci are beleived to be involved in this disease. recent studies have reported a strong genetic association between dtnbp1 (dystrobrevin-binding protein 1) gene variants and schizophrenia. methods: in this research, we used a case-control study to establish the possible association between the p1635 (rs3213207...

the engineering of transgenic canola (brassica napus l. ) to make tolerance to the broad-spectrum herbicide, glyphosate, is one of the most effective approaches for weed management. glyphosate inhibits the enzyme epsps (5-enolpyruvylshikimate-3-phosphate synthase) enzyme which functions in the shikimate pathway and has a key role in biosynthesis of aromatic amino acids required for survival of ...

this study was performed to investigate two polymorphic sites from cyp19 gene (pvuii and mspi) and one polymorphic site from erα gene (snabi) in four cattle breeds including mazandarani, taleshi, sistani and simmental. in overall 278 samples for cyp19 and 206 samples for erα marker sites were genotyped using polymerase chain reactionsingle-strand conformation polymorphism (pcr-rflp) procedure. ...