the johor strait is an estuarine system located on the coast of the state of johor in malaysia.the western part of johor strait is a shallow estuarine located between causeway and pulai river. ahydrodynamic model was calibrated based on the environmental fluid dynamic code (efdc) from 4th to 17th of october, 2009. in this calibration, the efdc hydrodynamic model was configured to simulate time ...

Although oxymatrine (OMT) has been shown to directly inhibit the replication of hepatitis B virus (HBV) in vitro, limited research has been done with this drug in vivo. In the present study, the antiviral effect of OMT was investigated in an immunocompetent mouse model of chronic HBV infection. The infection was achieved by tail vein injection of a large volume of DNA solution. OMT (2.2, 6.7 an...

Hepatitis B virus (HBV) reactivation and recurrence are common in patients under immunosuppression and can be controlled by hepatitis B immunoglobulin, antivirals, and hepatitis B vaccine. However, the detailed analysis of HBV infection under immunosuppression is essential for the prophylaxis and therapy for HBV reactivation and recurrence. In this study, HBV replication and T cell responses we...

Hydrodynamic tail vein (HTV) delivery is a simple and rapid tail vein injection method of a high volume of naked plasmid DNA resulting in high levels of foreign gene expression in organs, especially the liver. Compared to other organs, HTV delivery results in more than a 1000-fold higher transgene expression in liver. After being bitten by malaria-infected mosquitoes, malaria parasites transien...

The aim of the study is to investigate performance a thrust bearing equipped with hydrostatic lift pockets under different lubrication modes. Three types flat land modes are studied experimentally: (HS; forced oil injection pockets), hybrid (HS + HD; combined external supply) and hydrodynamic (HD; acting alone). Tests performed for steady transient states operation. obtained results confirmed t...

In antiviral therapy of hepatitis B virus (HBV) infection, drug resistance remains a huge obstacle to the long-term effectiveness of nucleoside/tide analogs (NAs). Primary resistance mutation (rtM204V) contributes to lamivudine (LAM)-resistance, and compensatory mutations (rtL180M and rtV173L) restore viral fitness and increase replication efficiency. The evaluation of new anti-viral agents aga...

Hepatitis B virus (HBV) is a prototype for liver-specific pathogens in which the failure of the immune system to mount an effective response leads to chronic infection. Our understanding of the immune response to HBV is incomplete, largely due to the narrow host restriction of this pathogen and the limitations of existing experimental models. We have developed a murine model for studying human ...

Hydrodynamic dispersion in flow through porous media is an essential phenomenon many geosystems. While of Newtonian fluids relatively well-understood, subsurface applications, such as groundwater remediation, use the flooding system with non-Newtonian fluids, polymer oxidants. Despite its significance, however, very limited studies have been carried out focusing on hydrodynamic fluids. The pres...

The use of a focused laser beam to create a sub-micron hole in the plasma membrane of a cell (photoporation), for the selective introduction of membrane impermeable substances (optical injection) including nucleic acids (optical transfection), is a powerful technique most commonly applied to treat single cells. However, particularly for femtosecond photoporation, these studies have been limited...

Sweeping is an effective and convenient way for online sample preconcentration in micellar electrokinetic chromatography. The usual procedure includes a hydrodynamic injection step carried out by applying pressure to the sample vial followed by the subsequent sweeping and separation processes. The injected sample volume is limited by the dimensions of the capillary because a part of the capilla...