Increases in intracellular and mitochondrial calcium content that accompany ischemic and toxic acute renal failure have been suggested to mediate renal tubular cell injury and dysfunction, but the mechanism(s) are unknown. We studied the effects of in vivo vitamin D-induced chronic hypercalcemia on rat renal cortical brush-border and basolateral membranes and mitochondria. In the brush-border m...

OBJECTIVE To describe the case of a child with paracoccidioidomycosis who presented hypercalcemia with multiple osteolytic lesions. DESCRIPTION A 6-year-old boy was admitted with a one-month history of fever and hepatosplenomegaly. On admission, he looked sick, pale, and had disseminated lymphadenopathy and hepatosplenomegaly. The laboratory findings included anemia (hemoglobin = 6.8 g/dl), e...

We report a male who exhibited the Landry-Guillain-Barre syndrome and hypercalcemia. He initially exhibited normocalcemia, followed by hypercalcemia which developed during tetraplegia and the recovering phase of the syndrome. The administration of prednisolone, saline, calcitonin, etidronate, and indomethacin failed to normalize the serum calcium level. Since, with mobilization, the serum calci...

INTRODUCTION Hypercalcemia is a known, but rare complication of histoplasmosis, a granulomatous disease. We present a case of chronic disseminated histoplasmosis, complicated by hypercalcemia, transiently worsening after initiation of antifungal treatment. CASE PRESENTATION A 61-year-old gentleman presented with shortness of breath, cough, weight loss, but no fever or hemoptysis. His physical...

It has been reported, mainly in Japan, that hypercalcemia and leukocytosis often coexist in malignancies, especially squamous cell carcinomas (1-4). Sato and his colleagues reported that squamous cell carcinoma with hypercalcemia and leukocytosis was successfully transplanted into nude mice, which caused granulocytosis and hypercalcemia and showed both boneresorbing and colony-stimulating activ...

Introduction: Necrotizing sarcoid granulomatosis (NSG) is a rare variant of sarcoidosis with pathologic features of necrosis and vasculitis that overlap with rheumatologic and infectious diseases. Hypercalcemia is occasionally the presenting feature of classical sarcoidosis occurring in 10–20% of patients, most commonly in association with pulmonary involvement. However hypercalcemia in NSG is ...

Parathyroid hormone-related protein (PTHrP) is considered to be one of the main causes of hypercalcemia associated with adult T-cell leukemia (ATL). To clarify the role of PTHrP and bone remodeling in the development of hypercalcemia in ATL, we examined the SCID mouse model of ATL that has previously been shown to mimic the disease in humans. Using this model, we found clear elevations in serum...

Primary squamous cell carcinoma of the colorectum is an unusual gastrointestinal cancer. These cancers have an uncertain pathogenesis, and the clinical literature provides limited information on the natural history and response to treatment. This report discusses a patient who presented with severe symptomatic hypercalcemia (21.08 mg/dL). Colonoscopy found a partially obstructing mass in the si...

BACKGROUND The ingestion of large amounts of milk and antacids to treat peptic ulcer disease was a common cause of hypercalcemia in the past (the "milk-alkali syndrome"). The current popularity of calcium and supplements has given rise to a similar problem. OBJECTIVES To evaluate the prevalence and characteristics of hypercalcemia induced by calcium intake ("calcium supplement syndrome"; or C...

Background: The effects of vitamin D on the skeletal system, biological metabolism, and immune system function are well shown. Cholecalciferol (vitamin D2) ergocalciferol (vitamin) 2 major types D. Vitamin D3 deficiency is worldwide intoxication induced by it very rare. Conclusion: involved in calcium hemostasis. acute hypercalcemia blood pressure were established. Hypercalcemia can elevate pre...