This report concerns the ultraviolet absorption and optical rotatory dispersion (ORD) of DNA and of nucleotides down to 185 mp. An absorption band (y) at about 195 mp occurs for all these compounds. Similar studies have been made on histones and nucleohistone. These indicate a strong absorption below 200 mp due to protein. Consequently, if any native DNA is associated with some amount (2 — 12%)...

The conformational change for the alternating purine-pyrimidine polydeoxyribonucleotides i.e. poly d(A-T), poly d(G-C), and poly d(A-C) poly d(G-T) from a right-handed conformation at room temperature to the left-handed Z-DNA like double helix at elevated temperatures has been studied by UV spectroscopy, Raman spectroscopy, and by adiabatic differential scanning microcalorimetry (DSC) in the pr...

Data have been obtained for the Pf1 virion that establish its stoichiometry and conformational features of its DNA and its protein. The absorbance spectrum of the dissociated virus under alkaline denaturing conditions is fit exactly by spectra for DNA and protein at a mole ratio of one nucleotide per protein subunit. This result, together with three previous values by independent methods, estab...

The association of anemia with pregnancy is well recognized. In this country the anemia is commonly due to iron deficiencies and is hypochromic. In the tropics a macrocytic, hyperchromic anemia of pregnancy has attracted attention and has been the subject of many recent investigations. Its counterpart in the temperate climates, the macrocytic or so-called pernicious anemia of pregnancy, has bee...

Bovine retinol-retinol-binding protein (RBP) was isolated from serum as a free, uncomplexed protein under experimental conditions in which human, rabbit, and chicken retinol-RBP are present as tight complexes with prealbumin (thyroxine-binding protein). Purified bovine retinol-RBP formed tight complexes with purified human and chicken prealbumin in physiological ionic strength buffers as judged...

Sarcoid is one of the most common skin tumours, which diagnosed in various breeds horses at any age regardless animal’s sex. Such fibroblastic neoplasm manifests itself several clinical ways with its specific morphological features. As a rule, it metastasizes rarely but can be locally invasive. The disease’setiology multifactorial and includes confirmed role bovine papillomavirus genetic enviro...

Aim of the study . To explore structural and functional changes neurons, glial cells, synaptic terminals in layers I, III, V sensorimotor cortex (SMC) rat brain after bilateral common carotid artery ligation (CCAL). Material methods Incomplete cerebral ischemia was simulated by irreversible CCAL (2-vessel model global without hypotension) on white rats (n=36). Comparative evaluation studied SMC...

nucleus are thought to be critical to the function of DNA as a coding template for messenger RNA synthesis (1, 3, 13, 30). Oligoamines and diamines have been reported to interact with DNA to raise the temperature at which the helix †" 4 coil transition occurs (10, 16†" 19, 31). Diamines, such as cadaverine, also protect against the dark inactiva tion of DNA in the presence of proflavine (10...

Dear Editor, AML is a group of heterogeneous diseases derived from various cytogenetic and molecular abnormalities that are significant for diagnosis, treatment, and prognosis in many cases. We report a rare case of AML harboring t(11;19)(p15;p12) that was detected with whole-genome sequencing (WGS). A 33-yr-old woman was admitted to a local hospital with abdominal pain and diarrhea for five da...