Abstract St. John’s wort ( Hypericum perforatum ) is a medicinal plant with rich history of traditional use. It has been shown to possess range beneficial health properties, including antioxidant and anti-inflammatory activities. In this study, the content flavonoids activity commercially available dried wild-grown samples were analyzed using LC–MS/MS method. addition, these evaluated for their...

The modifications induced by hypericin on the electric properties of the artificial lipid bilayers suggest that it has apparent stabilizing effects on the membrane against strong chaotropic anions. We imply that this is due to the interference of hypericin’s insertion into the bilayers with the mechanisms by which the lyotropic anions alter the electrical surroundings of the bilayer and/or the ...

Hypericin-mediated photodynamic therapy (HY-PDT) has become a potential treatment for tumors and nonmalignant disorders. Some studies reported that HY-PDT could lead to apoptosis in some carcinoma cells. However, the molecular mechanism of HY-PDT remains unknown. In this study, we evaluated the molecular mechanisms of hypericin associated with light-emitting diode irradiation on the poorly diff...

The Evolution of Increased Competitive Ability (EICA) hypothesis predicts that introduced plants should lose enemy resistance and in turn evolve increased size or fecundity. We tested the first prediction of this hypothesis by growing introduced North American and native European genotypes of St. John’s Wort (Hypericum perforatum) in common gardens in the state of Washington, USA, and in Girona...

Plant endophytic fungi are an important and novel resource of natural bioactive compounds with their potential applications in agriculture, medicine and food industry. In the past two decades, many valuable bioactive compounds with antimicrobial, insecticidal, cytotoxic and anticancer activities have been successfully discovered from the endophytic fungi. During the long period of co-evolution,...

Aim: To identify the hypericin content in Hypericum gaitii Haines through HPTLC & FTIR, an endangered medicinal plant and potential for curing many diseases like cancer, AIDS, tumour etc. Methods: Methanolic extract of leaves derived from in vitro raised plants were used in the mobile phase of Toluene: Ethyl acetate: Formic acid (10:8:3) and scanned under UV at 254nm and 366 nm and under visibl...

Dried buckwheat herb is used in medicinal products whereas fresh green plant parts, especially sprouts, are consumed as a vegetable. The herb contains fagopyrins, which cause sensitivity to light after ingestion. The aim of this study was to investigate the impact of different growing conditions and the development phase on the content of fagopyrin and phenolic compounds in buckwheat sprouts. T...

Residual tumor resulting in tumor recurrence after various anticancer therapies is an unmet challenge in current clinical oncology. This study aimed to investigate the hypothesis that radioiodinated hypericin (131I-Hyp) may inhibit residual tumor recurrence after microwave ablation (MWA) on rat orthotopic liver allograft sarcoma models.Thirty Sprague-Dawley (SD) rats with hepatic tumors were di...

Hypericum perforatum (St. John's wort) is well-established for its antidepressant activity throughout the world and also various other species within this genus are used in different folk medicines. Hyperforin of St. John's wort inhibited growth of cancer cell lines and the use of hypericin (another compound of H. perforatum) in cancer photodynamic therapy is proposed. Therefore, we investigate...