In the present work we carried out a phytochemical and biological investigation on three endemic Hypericum species, i.e. Hypericum thymbrifolium, Hypericum spectabile and Hypericum pseudolaeve from Anatolia in order to discover new sources of natural compounds for the treatment of inflammatory and neurodegenerative disorders. HPLC-DAD analysis indicated that two naphthodianthrones (pseudohyperi...

Introduction: Hypericum perforatum L was coded in medicinal plants research center of Shaheed Beheshti university and using decoction method was extracted. There are many reports concerning the antidepressant effects of Hypericum perforatum L. (HP), but there are few studies indicating its antinociceptive effects of Hypericum specially Hypericum perforatum L. Materials & Methods: In this expe...

conclusions ehp was able to both reduce ldl-ch and to significantly decrease markers of oxidative stress and lipid peroxidation induced by hyperlipidemia. therefore, this herb, as a new pharmacological component, could be used to reduce certain blood lipids, lipid peroxidation, and aminotransferase markers. materials and methods thirty-two male rats weighting 200 ± 10 g were randomly divided in...

A new simple phloroglucinol derivative characterized as 1-(6-hydroxy-2,4-dimethoxyphenyl)-2-methyl-1-propanone (1) was isolated from Hypericum cistifolium (Hypericaceae) as a major constituent of the non-polar plant extract. Minor amounts of this new compound, in addition to two known structurally related phloroglucinol derivatives (2 and 3), and two new terpenoid derivatives characterized, res...

Recent decades have seen development of research and an increased interest in the psychopharmacology of natural remedies. More than 20 herbal remedies have been identified that may potentially be applied in medicine as antidepressive, anxiety relieving or sleep-inducing agents. Patients often prefer to take herbal remedies and often take them on their own, without consulting a physician. The ai...

Within the framework of our continuous efforts to explore Hypericum species from Jordan, we report the analysis of the major active metabolites, naphthodianthrones and phloroglucinols, in the methanolic extracts of two under-explored Hypericum species; H. empetrifolium Willd. and H. sinaicum Hochst. & Steud. ex Boiss., using LC-(+,-)-ESI-MS (TIC and SIM) and LC-UV/Vis spectroscopy. Based on the...

Abstract Three new compounds ( 1 – 3 ) with unusual skeletons were isolated from the n -hexane extract of air-dried aerial parts Hypericum scabrum . Compound represents first example an esterified polycyclic polyprenylated acylphloroglucinol that features a unique tricyclo-[4.3.1.1 1,4 ]-undecane skeleton. 2 is fairly simple MPAP, but unexpected cycloheptane ring decorated prenyl substituents, ...