Hypertrophic obstructive cardiomyopathy (HOCM) is an obstructive subvariety of hypertrophic cardiomyopathy. In hypertrophic cardiomyopathy, the left ventricular wall of the heart is abnormally thick, and the left ventricular cavity is small. HOCM is characterized by an excessively thick interventricular septum, which obstructs left ventricular outflow during ventricular systole. Pericardial tam...

Hypertrophic cardiomyopathy (HCM) is an autosomal dominant heart disease that is the most common genetic cardiac disorder. The disease is characterized by excessive thickening of the left ventricular myocardium. The anterior portion of the interventricular ventricular septum is often involved. Asymmetric hypertrophy of apical site, left ventricular free wall, and right ventricle are less common...

Hypertrophic cardiomyopathy is a fascinating disease of marked heterogeneity. Hypertrophic cardiomyopathy was originally characterized by massive myocardial hypertrophy in the absence of known etiology, a dynamic left ventricular outflow obstruction, and increased risk of sudden death. It is now well accepted that multiple mutations in genes encoding for the cardiac sarcomere are responsible fo...

Editorial Genetic investigation and counselling of families with hypertrophic cardiomyopathy In 1958 Teare described the gross appearances of the heart in eight young people dying suddenly of what became known as hypertrophic cardiomyopathy.' The familial nature of the disease became clear when Teare found himself carrying out a necropsy on a brother of a case in the series. By coincidence on t...

Phospholamban is an endogenous inhibitor of sarcoplasmic reticulum calcium ATPase and plays a prime role in cardiac contractility and relaxation. Phospholamban may be a candidate gene responsible for cardiomyopathy. We investigated genome sequence of phospholamban in patients with cardiomyopathy. PCR-based direct sequence was performed for the promoter region and the whole coding region of phos...

Left ventricular hypertrophy (symmetric, asymmetric, or hypertrophic cardiomyopathy) is an almost invariable accompaniment of primary hyperparathyroidism. Five of 18 patients with hypertrophic cardiomyopathy had raised serum concentrations of parathyroid hormone with normal serum calcium concentrations. Left ventricular hypertrophy did not occur in any of the six patients with hypercalcaemia al...