INTRODUCTION Cardiopulmonary bypass surgery is associated with a systemic inflammatory response through the interaction of air, blood and synthetic components in the bypass system and the physical trauma of surgery. An alternative cardiopulmonary bypass system, minimal extracorporeal circulation (MECC), has shown promising results in terms of reducing the inflammatory response. We hypothesized ...

OBJECTIVE To compare the clinical response of keloidal and hypertrophic scars after treatment with intralesional corticosteroid alone or combined with 5-fluorouracil (5-FU), 5-FU alone, and the 585-nm flashlamp-pumped pulsed-dye laser (PDL). DESIGN Prospective, paired-comparison, randomized controlled trial. SETTING A private ambulatory laser facility. PATIENTS Ten patients with previousl...

Hypertrophic scarring is a common proliferative disorder of dermal fibroblasts characterized by collagen overproduction and excessive deposition of extracellular matrix (ECM). There is no consensus about the best therapeutics to produce complete and permanent improvement of scars with few side effects. To investigate the therapeutic effects of oleanolic acid (OA) on hypertrophic scars and explo...

Hypertrophic scar is a complication of wound healing and has a high recurrence rate which can lead to significant abnormity in aesthetics and functions. To date, no ideal treatment method has been established. Meanwhile, the underlying mechanism of hypertrophic scarring has not been clearly defined. Although a large amount of scientific research has been reported on the use of medicinal plants ...

UNLABELLED  Collagen synthesis and degradation are important in scar maturation. Collagenase has been used for debridement of wounds and treatment of Dupuytren's disease but its effects on scar prevention are unknown. OBJECTIVE The objective of this study was to determine the effect of collagenase ointment on hypertrophic scar prevention by using a rabbit ear-scarring model. METHODS F...

BACKGROUND AND OBJECTIVE To determine the efficacy and safety of the ThermaCool TC radiofrequency system for treatment of hypertrophic and keloid scars and evaluate treatment associated collagen changes. MATERIALS AND METHODS Six subjects with hypertrophic and four with keloid scars were treated with the ThermaCool device: one-third of the scar received no treatment (control), one-third recei...

OBJECTIVE The aim of the present study was to explore the potential for hematoporphyrin monomethyl ether-Sonodynamic Therapy (HMME-SDT) treatment of hypertrophic scars within rabbit ears. METHODS 60 white rabbits were randomly divided into five groups: (1) untreated controls, (2) lesioned, (3) lesioned + HMME, (4) lesioned + US (Ultrasound), and (5) lesioned +HMME-SDT. After induction of a le...

To detect the expression pattern of c-Jun in human hypertrophic scars and investigate its role in regulation of cell proliferation and apoptosis in fibroblasts and its underlying action mechanism. In this study, we examined the expression of c-Jun in hypertrophic scars and fibroblasts using quantitative real-time polymerase chain reaction and western blot analysis and investigated the functiona...

PURPOSE OF REVIEW Abnormal scarring remains a poorly understood but functional and aesthetic consequence of surgical and traumatic wounds. The purpose of this review is to describe the current state of the science behind the prevention and management of these scars. RECENT FINDINGS A recent update in the International Clinical Recommendations on Scar Management provides a wealth of informatio...