Tamoxifen (TAM), a non-steroidal antiestrogen, has revolutionized female breast cancer treatment. The mechanism involves is to compete with 17β-estradiol (E2) at the receptor site and blocking promotional role of E2 in cancer. Tam pioneering medicine because its widespread usage treatment chemoprevention, as well research into novel selective estrogen modulators (SERMs). In vast majority patien...

The rapid increase of biomedical literature available on the web has made it increasingly difficult to find precise information. To implement an accurate biomedical information retrieval (IR) system, we must deal with the variants of biomedical terms carefully. In this paper, we focus on the generation of aliases, synonyms, acronyms, and lexical variants of such terms. In addition, we also prop...

This paper was aimed at characterizing the wine obtained from Oblačinska, a native sour cherry cultivar. To the best of our knowledge, this is the first paper with the most comprehensive information on chemical characterization of Oblačinska sour cherry wine. The chemical composition was characterized by hyphenated chromatographic methods and traditional analytical techniques. A total of 24 com...

The present Art. 20.3 needs to be clarified by stating its main clause positively, not negatively as at present. As currently worded, it could give the false impression that a generic name formed from two words combined into one is admissible, although Quisqualis in current Ex. 8 (our 7 below) shows this intention. Also, Examples made more understandable slight modifications and rearrangement. ...

UHPLC-DAD-HRMS based dereplication guided the detection of new halogenated alkaloids co-produced by Talaromyces wortmannii. From the fungal growth in large scale, the epimers 2,8-dichlororugulovasines A and B were purified and further identified by means of a HPLC-SPE/NMR hyphenated system. Brominated rugulovasines were also detected when the microbial incubation medium was supplemented with br...

The term ‘dimension’ in the above titles refers to the use of a ‘dimension of chromatography’ – or put more simply, a column – or for multidimension – two or more columns. In the broad sense, a ‘dimension of analysis’ is any technique that provides independent analysis capability. So FTIR, MS, and GC are discrete dimensions; they can be operated independently to provide some measure of analysis...

Industrial organic synthesis is time and energy consuming, generates substantial waste. Traditional conductive heating mixing in batch reactors no longer competitive with continuous-flow synthetic methods enabling technologies that can strongly promote reaction kinetics. These advances lead to faster simplified downstream processes easier workup, purification process scale-up. In the current In...