نتایج جستجو برای: hypohidrotic ectodermal dysplasia

تعداد نتایج: 30775  

Journal: : 2023

Genomic technologies in archaeology have been used to study migration patterns, origin of and genetic similarity between ancient populations. Researchers are, however, just beginning employ these evaluate the genomic health communities. In this we screen publicly available whole-genome sequencing data pre-contact Caribbean individuals for presence pathogenic mutations causing monogenic diseases...

Journal: :iranian journal of allergy, asthma and immunology 0
farzaneh motamed fariborz zieh mostafa sedighi

in this case report we will describe a rare association between anhyrotic ectodermal dysplasia (aed) and immunodeficiency and autoimmunity [in our case: idiopathic thrombocytopenic purpura (itp) and crohn disease]. aed is a rare congenital disorder characterized by sparse hair, abnormal teeth and anhidrosis due to lack of eccrine glands. the survey of 87 cases with (aed) revealed only one irrit...

2003
Gilles Courtois Asma Smahi Janine Reichenbach Rainer Döffinger Caterina Cancrini Marion Bonnet Anne Puel Christine Chable-Bessia Shoji Yamaoka Jacqueline Feinberg Sophie Dupuis-Girod Christine Bodemer Susanna Livadiotti Francesco Novelli Paolo Rossi Alain Fischer Alain Israël Arnold Munnich Françoise Le Deist Jean-Laurent Casanova

The Journal of Clinical Investigation | October 2003 | Volume 112 | Number 7 Introduction Patients with anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) present with impaired development of skin appendices, resulting in sparse hair, conical teeth, and anhidrosis/hypohidrosis. Host defense is also impaired, resulting principally in multiple and severe bacterial diseases (1). X-link...

Journal: :Blood 2012
Tomoki Kawai Ryuta Nishikomori Kazushi Izawa Yuuki Murata Naoko Tanaka Hidemasa Sakai Megumu Saito Takahiro Yasumi Yuki Takaoka Tatsutoshi Nakahata Tomoyuki Mizukami Hiroyuki Nunoi Yuki Kiyohara Atsushi Yoden Takuji Murata Shinya Sasaki Etsuro Ito Hiroshi Akutagawa Toshinao Kawai Chihaya Imai Satoshi Okada Masao Kobayashi Toshio Heike

Somatic mosaicism has been described in several primary immunodeficiency diseases and causes modified phenotypes in affected patients. X-linked anhidrotic ectodermal dysplasia with immunodeficiency (XL-EDA-ID) is caused by hypomorphic mutations in the NF-κB essential modulator (NEMO) gene and manifests clinically in various ways. We have previously reported a case of XL-EDA-ID with somatic mosa...

2016
Shahram Torkamandi Milad Gholami Javad Mohammadi-asl Somaye Rezaie Mohammad Ali Zaimy Mir Davood Omrani

Hypohidrotic ectodermal dysplasia (HED) is a rare congenital disorder arising from deficient development of ectoderm-derived structures including skin, nails, glands and teeth. The phenotype of HED is associated with mutation in EDA, EDAR, EDARADD and NEMO genes, all of them disruptingNF-κB signaling cascade necessary for initiation, formation and differentiation in the embryo and adult. Here w...

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