Introduction. Cannabis sativa is a source of oil seeds for pharmaceutical, cosmetic, and food uses. Objective. The aim this study to evaluate the hypolipidemic effect hemp seed (HSO) obtained from local ecotype called “Beldiya.” Methods. extraction HSO was carried out by cold press method. Then, fatty acid tocopherol composition analyzed, respectively, GC-FID HPLC. activity at dose 3.5 7 mg/kg ...

Because diabetes confers a very high risk of cardiovascular morbility and mortality, an aggressive hypolipidemic and antiplatelet treatment has been strongly recommended in the whole diabetic population. In particular, patients who have diabetes should be considered in "secondary prevention" even before presenting cardiovascular events, because diabetes is a "coronary heart disease equivalent."...

Hypolipidemic drugs increased 3to 4-fold the activity of the peroxisomal &oxidation system in rat liver, with modest or no effects on catalase activity, liver weight, or peroxisome abundance. This specificity of action was observed in two experimental models: 7) bezafibrate treatment of male rats (25 mg/kg body wt., p.0.) and 2) clofibrate treatment of female rats (5 g/kg chow). Bezafibrate had...

Hyperlipidemia is a major contributor for atherosclerosis and hypolipidemic drugs such as statin are highly prescribed to treat elevated lipid level in plasma. Rubus coreanus, which is widely cultivated in south eastern Asia, have been reported to show significant cholesterol lowering action in hyperlipidemic subjects. Our objective was to determine the cellular effect of Rubus coreanus extract...

The aim of this study was to investigate the hypolipidemic effect of the total flavonoids from mulberry leaves (MTF) in hyperlipidemic mice. The total flavonoids have been isolated from mulberry (Morus alba L.) leaves and purified by macroporous resins. After that, the content of MTF is 581.7 mg g-1 in dried product. The hypolipidemic effect of MTF has been evaluated in triton WR-1339 (400 mg k...

The present study was designed to clarify the significance of complex formation of lipoproteins with extracellular connective tissue macromolecules during lipid accumulation in the arterial wall in SPF rabbits fed on a 0.5% cholesterol diet for six weeks. The effect of pantethine, a new hypolipidemic drug, on their complex formation and lipid accumulation was also studied. The levels of cholest...

Tetradecylthioacetic acid (TTA) is a novel peroxisome proliferator-activated receptor (PPAR) ligand with marked hypolipidemic and insulin-sensitizing effects in obese models. TTA has recently been shown to attenuate dyslipidemia in patients with type 2 diabetes, corroborating the potential for TTA in antidiabetic therapy. In a recent study on normal mice, we showed that TTA increased myocardial...

Animal and human clinical studies have demonstrated the ability of dietary food proteins to modulate endogenous lipid levels during abnormal lipid metabolism (dyslipidemia). Considering the susceptibility of proteins to gastric proteolytic activities, the hypolipidemic functions of proteins are possibly due, in part, to their peptide fragments. Food-derived peptides may directly modulate abnorm...

OBJECTIVE The effect of n-3 polyunsaturated fatty acids on the serum lipid profile in a Mexican population was evaluated. MATERIAL AND METHODS Three g of salmon oil was the daily intake during four weeks. Total cholesterol, triglycerides, low density lipoproteins, high density lipoproteins and erythrocyte fatty acid composition were analyzed. RESULTS The hypertriglyceridemic group showed a ...