نتایج جستجو برای: i 125
تعداد نتایج: 1065598 فیلتر نتایج به سال:
PURPOSE Prostate-specific membrane antigen (PSMA) is a cell surface protein that is overexpressed in prostate cancer, including hormone-refractory and metastatic disease. Our goal in this study was to develop a series of PSMA-based imaging agents for clinical use. EXPERIMENTAL DESIGN We have synthesized and evaluated the in vivo biodistribution of two radiolabeled urea derivatives that have h...
Antibodies are a diverse class of glycoproteins that specially bind with antigen and elicit a number of secondary responses in vivo. Most of the applications of antibodies in basic research diagnosis and immunotherapy rely on labeling of the antibody with radiopharmaceuticals. Radiolabeled antibodies are a new class of imaging agents for the detection of sites of disease. True biodistribu...
Detecting aggregated amyloid peptides (Abeta plaques) presents targets for developing biomarkers of Alzheimer's disease (AD). Polymeric n-butyl-2-cyanoacrylate (PBCA) nanoparticles (NPs) were encapsulated with radiolabelled amyloid affinity (125)I-clioquinol (CQ, 5-chloro-7-iodo-8-hydroxyquinoline) as in vivo probes. (125)I-CQ-PBCA NPs crossed the BBB (2.3 +/- 0.9 ID/g) (P < .05) in the WT mous...
BACKGROUND RADIOIODINE IS ROUTINELY USED OR PROPOSED FOR DIAGNOSTIC AND THERAPEUTIC PURPOSES: (123)I, (125)I and (131)I for diagnostics and (125)I and (131)I for therapy. When radioiodine-labelled pharmaceuticals are administered to the body, radioiodide might be released into the circulation and taken up by the thyroid gland, which may then be an organ at risk. The aim of this study was to com...
این آزمایش در سال زراعی 90- 1389 به صورت کرتهای خرد شده در قالب طرح بلوکهای کامل تصادفی با سه تکرار در ایستگاه تحقیقات کشاورزی بایعکلاء (نکاء) اجرا شد. عامل اصلی دور آبیاری شامل 1i، 2 i، 3i و 4 i(به ترتیب 75 ، 100 ، 125 و 150 میلیمتر تبخیر تجمعی از تشت تبخیر) و عامل فرعی نیتروژن معادل صفر،200 و 400 کیلوگرم اوره در هکتار بود. نتایج نشان داد بیشترین عملکرد علوفهتر در هکتار با مصرف 184 کیلوگ...
Derivatives of salicylic acid (SA) and benzoic acid prevent endothelin-1 (ET-1) binding to ETA receptors. This study analyzed actions of 30 derivatives of benzoic acid and salicylic acid on (125)I-ET-1 binding to recombinant rat ETA receptors. The most active compounds were 3,5-dibromosalicylic acid (Br2SA, K(i) = 0.5 mM) and 3,5-diiodosalicylic acid (K(i) = 0.3 mM). They were about 50 times mo...
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