In 2010 HP® introduced three new server blades and an update to OpenVMS® that will extend the life of the OpenVMS environment for many years. The BL8x0c i2 server blades use quad-core Intel® Itanium® 9300 processors. OpenVMS V8.4 offers improved performance designed for these new BL8x0c i2 server blades. This paper provides detailed analyses of the performance advantages of OpenVMS V8.4 running...

As with many min-max characterizations, proving one of the inequalities is straightforward. For any U ⊆ S and I ∈ I1 ∩ I2, we have |I| = |I ∩ U |+ |I ∩ (S \ U)| ≤ r1(U) + r2(S \ U), since I ∩ U is an independent set in I1 and I ∩ (S \ U) is an independent set in I2. Therefore, maxI∈I1∩I2 |I| ≤ minU∈S (r1(U) + r2(S \ U)). The following important examples illustrate some of the applications of th...

In a previous study we observed that the ability of intravenous infusions of prostaglandin I2 to attenuate vasoconstriction caused by intravenous infusions of angiotensin II was reduced in the renal but not mesenteric vasculature of spontaneously hypertensive rats (SHR). One objective of the current study was to determine whether a renal defect in the angiotensin II/prostaglandin I2 interaction...

Apomyoglobin folding proceeds through a molten globule intermediate (low-salt form; I1) that has been characterized by equilibrium (pH 4) and kinetic (pH 6) folding experiments. Of the eight alpha-helices in myoglobin, three (A, G, and H) are structured in I1, while the rest appear to be unfolded. Here we report on the structure and stability of a second intermediate, the trichloroacetate form ...

In this meta-analysis, we assessed cardiac magnetic resonance imaging data to determine the effects of local and remote ischemic postconditioning (LPoC and RPoC, respectively) on structural pathology in ST-segmentel elevation acute myocardial infarction (STEMI). We searched the Pubmed, Embase and Cochrane Library databases up to May 2017 and included 12 randomized controlled trials (10 LPoC and...

The effect of prostaglandin I2 and two other vasodilator agents, acetylcholine and sodium nitroprusside, on systemic and renal circulation was studied in 29 adult euvolemic Sprague-Dawley rats. Intra-aortic infusion of prostaglandin I2 (3.6 micrograms/kg/hr; n = 6 rats) produced significant vasodilation (p less than 0.05), as indicated by an average reduction in total peripheral vascular resist...

UDP-glucuronosyltransferases (UGTs) are major mediators in conjugative metabolism. Current data suggest that UGTs, which are anchored in the endoplasmic reticulum membrane, can oligomerize with each other and/or with other metabolic enzymes, a process that may influence their enzymatic activities. We demonstrated previously that the UGT1A locus encodes previously unknown isoforms (denoted "i2")...

Potato spindle tuber viroid (PSTVd) is one of the smallest (about 360 nt) infectious plant agents. It is composed of a single-stranded circular non-coding RNA molecule. In the course of previous passage experiments with two intermediate PSTVd variants I2 and I4, three non-infectious clones (I2-50, I4-37 and I4 VI-17) were found. When inoculated separately as cDNAs on tomato "Rutgers" test plant...

The influence of in vivo melatonin administration on in vitro pituitary follicle stimulating hormone (FSH), growth hormone (GH) and prolactin secretion, as well as the possible influence of dopamine (DA) were evaluated in prepubertal (31-day-old), pubertal (33-day-old) and adult female rats at diestrus phase of the sexual cycle. The in vitro pituitary hormone secretions were evaluated at basal ...

BackgroundImmune checkpoint inhibitors (ICIs) are standard of care in advanced non-small cell lung cancer (NSCLC), however their status patients with poor performance (PS) is poorly defined. We aimed to evaluate the efficacy and safety ICIs NSCLC PS ? 2.MethodsWe conducted a systematic review meta-analysis interventional observational studies, which reported data on 2 comparing ? 1 patients. Ef...