Background/Aims Fructose malabsorption (FM) mimics symptoms of irritable bowel syndrome (IBS), and its prevalence has increased. Diagnosing FM in IBS is challenging because of its overlap with small intestinal bacterial overgrowth (SIBO). We assessed the prevalence of FM by comparing patients with IBS with asymptomatic control individuals after excluding SIBO using the glucose hydrogen breath t...

Nociceptin/orphanin FQ (N/OFQ) and the N/OFQ peptide (NOP) receptor play important roles in regulating gastrointestinal function. To assess whether the NOP receptor is implicated in the etiopathogenesis of irritable bowel syndrome (IBS), we measured the levels of NOP receptor mRNA and protein in the jejunal and colonic tissues of healthy subjects and patients with diarrhea-predominant IBS (D-IB...

Background: Migraine and irritable bowel syndrome (IBS) are chronic conditions that seem to share common pathophysiological aspects. Objectives: Our study aimed to estimate the prevalence of IBS in an Iranian migraine population, investigate its association with headache's characteristics and depression. Materials and Methods: This cross-sectional study was done in a tertiary hospital cli...

Irritable Bowel Syndrome (IBS) is a common multi-factorial disorder affecting approximately 12% of the populations worldwide resulting in significant global morbidity1. Approximately one in ten patients with Irritable Bowel Syndrome (IBS) believes that their IBS began with an infectious illness. The persistence of these symptoms about the clearance of infecting pathogen is known as post infecti...

OBJECTIVES To review unmet medical needs associated with irritable bowel syndrome (IBS), to discuss factors that contribute to these unmet needs, and to provide an overview of advancements in IBS diagnosis and treatment options that may influence treatment strategies. SUMMARY IBS is characterized by a multiple symptom complex of abdominal pain or discomfort and altered bowel habits (i.e., con...

TO THE EDITOR: Irritable bowel syndrome (IBS) is very common, although it is not a life-threatening condition. Although in Western countries, up to 20% of adults suffer from IBS, including those who have not consulted physicians, the prevalence in Eastern countries tends to be lower and ranges from 6.5% to 10.1%. It usually gives an impact on quality of life through clinical symptoms, consultat...

BACKGROUND Irritable bowel syndrome (IBS) is a common gastrointestinal disorder. The prevalence of IBS in Asian countries varies from 2.9% to 15.6%. IBS does not result in increased mortality, but is associated with psychological distress and disruption of work and sleep. Consequently, the evaluation of health-related quality of life (HRQoL) is an important outcome measure for patients with IBS...

AIMS Irritable bowel syndrome (IBS) is a functional gastrointestinal (GI) disorder, associated with alterations of bowel function, abdominal pain and other symptoms related to the GI tract. Recently the endogenous cannabinoid system (ECS) was shown to be involved in the physiological and pathophysiological control of the GI function. The aim of this pilot study was to investigate whether IBS de...

Irritable bowel syndrome (IBS) is a common gastrointestinal disorder with an estimated prevalence of 10-20%. Current understanding of the pathophysiology of IBS is incomplete due to the lack of a clearly identified pathological abnormality and due to the lack of reliable biomarkers. Possible mechanisms believed to contribute to IBS development and IBS like symptoms include physical stressors, s...

INTRODUCTION Irritable bowel syndrome (IBS) is a functional bowel disorder characterized by chronic or recurrent abdominal pain in association with defecation or a change in bowel habits. A predominant disorder of bowel habits, IBS is classified into three main subtypes: constipation-predominant IBS (IBS-C), diarrhea-predominant IBS (IBS-D) and IBS alternating between constipation and diarrhea ...