Abstract Colorectal cancer (CRC) is the 2 nddeadliest globally and has 3 rdhighest incidence mortality in United States. Advanced-stage disease incurable by current clinical standards. Thus, alternative treatments are being explored, including immune checkpoint blockade (ICB) to prevent T cell inactivation tumors. ICB induces a robust response patients with microsatellite instability-high (MSI-...

Abstract Brain tumors reside in a modified microenvironment where inflammatory processes are heavily regulated. Nevertheless, our recent study showed significant immune infiltration recurrent glioblastoma (rGBM) treated with neoadjuvant PD-1 checkpoint blockade therapy. In comparison to GBM, the intracranial response of brain metastases (BrM) immunotherapy has been less well studied. To test th...

&&v,w To assess the penetration of Iossrtan and L-158,338 into the rabbit eye after topical application and their effects on the IOP of ocular hypertensive cynomolgus monkeys. M&Q& Penetration was indirectly assessed in albino rabbits using an & assay. Aliquots of aqueous humor were sampled one hour after the bilateral topical instillation of one drop (50 uL) of 2% solutions of losartsn or L-15...

The spring bloom is a key annual event in the phenology of pelagic ecosystems, making a major contribution to the oceanic biological carbon pump through the production and export of organic carbon. However, there is little consensus as to the main drivers of spring bloom formation, exacerbated by a lack of in situ observations of the phytoplankton community composition and its evolution during ...

Supplementary Information Reduced graphene oxide: Firm support for catalytically active palladium nanoparticles and game changer in selective hydrogenations Manuela Cano, Ana M. Benito, Esteban P. Urriolabeitía, Raul Arenal and Wolfgang K. Maser ICB-CSIC, E-50018 Zaragoza, Spain. [email protected] ISQCH-CSIC-Univ. Zaragoza, E-50009 Zaragoza, Spain LMA-INA-Univ. Zaragoza, E-50018 Zaragoza, Spai...

Critical success factors such as trust and privacy concerns have been recognized grand challenges for research of intelligent interactive technologies. Not only their ethical, legal, social implications, but also role in the intention to use these technologies within high risk uncertainty contexts must be investigated. Nonetheless, there is a lack empirical evidence about influencing user’s ins...

Assessment rubrics are recognized for their positive effects, being defined as an evaluative instrument that establishes assessment criteria and performance levels. In this sense, can be associated with professional practices more authentic processes. the context of Project Management, International Management Association (IPMA) has developed a framework individual competences professionals wor...

PROBLEMA: la Educación Remota de Emergencia (ERE) ocasionada por pandemia representó una improvisación sin precedente, lo cual provoco incertidumbre en los estudiantes ante funcionalidad evaluación del aprendizaje curso Interpretación consecutiva bilateral (ICB). OBJETIVO: describir percepción ICB Nueva Normalidad Virtual (NNV) carrera Licenciatura Ciencias Lingüísticas Universidad San Carlos G...

&&v,w To assess the penetration of Iossrtan and L-158,338 into the rabbit eye after topical application and their effects on the IOP of ocular hypertensive cynomolgus monkeys. M&Q& Penetration was indirectly assessed in albino rabbits using an & assay. Aliquots of aqueous humor were sampled one hour after the bilateral topical instillation of one drop (50 uL) of 2% solutions of losartsn or L-15...