The following chapter from Evolutionary Game Design (Browne 2011) describes Yavalath, the first computer-generated board game to be commercially published. LUDI is a software system that creates new combinatorial games by evolving the rule sets of known games into new combinations, then testing them for playability and quality. It was developed as a proof-of-concept for my 2008 PhD thesis Autom...

PURPOSE Trabeculectomy has been regarded as a mainstay of initial treatment in eyes of angle closure glaucoma (ACG) with peripheral anterior synechia > 180° in the Chinese population while its efficacy in secondary ACG with BEST1 gene mutation remains unclear. We set out to investigate the treatment outcome of trabeculectomy for secondary ACG in a group of patients with autosomal recessive best...

The 4th Computers and Games conference was held in Ramat-Gan, Israel on July 5 to 7, 2004. After two conferences in Japan and one in Canada, it was the first time that Israel hosts this major event which was organised by the ICGA and the Institute for Knowledge and Agent Technology (IKAT). The conference was organised in conjunction with two other events: the 12th World Computer Chess Champions...

In June 2011, the International Computer Games Association (ICGA) disqualified Vasik Rajlich and his Rybka chess program for plagiarism and breaking their rules on originality in their events from 2006-10. One primary basis for this came from a painstaking code comparison, using the source code of Fruit and the object code of Rybka, which found the selection of evaluation features in the progra...

PURPOSE To improve selectivity of verteporfin therapy (PDT) in neovascular age-related macular degeneration (AMD) using modified treatment parameters. METHODS Nineteen consecutive patients with predominantly classic choroidal neovascularization (CNV) in AMD were treated with 6 mg/m2 verteporfin given as bolus infusion. Patients received PDT with a fluence of either 25 or 50 J/cm2. Choroidal p...

Purpose. To report an association between reticular pseudodrusen, located above the retinal pigment epithelium (RPE), and Early Onset Drusen (EOD) as described using Spectral-Domain Optical Coherence Tomography (SD-OCT). Methods. Eight patients (16 eyes) with EOD were examined. EOD were classified into three entities called Large Colloid Drusen (LCD), Malattia Leventinese (ML), and Cuticular Dr...

Subretinal neovascular membranes (SRNM) are a deleterious complication of laser eye injury and retinal diseases such as age-related macular degeneration (AMD), choroiditis, and myopic retinopathy. Photodynamic therapy (PDT) and anti-vascular endothelial growth factor (VEGF) drugs are approved treatment methods. PDT acts by selective dye accumulation, activation by laser light, and disruption an...

PURPOSE To evaluate a new angiographic technique that offers three-dimensional imaging of chorioretinal vascular diseases. METHODS Fluorescein (FA) and indocyanine green angiography (ICGA) were performed using a confocal scanning laser ophthalmoscope. Tomographic series with 32 images per set were taken over a depth of 4 mm at an image frequency of 20 Hz. An axial analysis was performed for e...

PURPOSE Age-related macular degeneration (AMD) is the main cause of visual impairment and legal blindness in older individuals. COL8A1 rs13095226 variants have recently been implicated associated with neovascular age-related macular degeneration (nAMD) and Polypoidal Choroidal Vasculopathy (PCV) in American studies. The aim of this study was to investigate the association between the COL8A1 rs1...

This note corrects a previous treatment of algorithms for the metric DTR, Depth by the Rule. Haworth (2000) addressed optimal winning strategies for chess endgames, given the constraint of the 50-move rule. It proposed the revival of the Depth to Zeroing-move metric DTZ, to be used with the familiar DTC, Depth to Conversion, and DTM(ate) metrics. It also introduced the new DTR metric, Depth by ...