SUMMARY IE-Kb (Intron Exon-Knowledge base) illustrates the intron-exon dynamics in eukaryotic genes. We have developed three different knowledge sets, namely 'Non-redundant ExInt', 'Non-redundant Pfam-ExInt complement' and 'Non-redundant GenBank eukaryotic subdivisional sets' to understand this phenomenon. Statistical analysis is performed on each knowledge set and the results are made availabl...

BACKGROUND We report herein a novel strategy for the preparation of protein-based nanodelivery vehicles for hydrophobic active pharmaceutical ingredients. METHODS The procedure consisted of three steps, ie, exposure of hydrophobic residues of a protein to a pH-induced partial unfolding: interaction between hydrophobic residues on the protein and the hydrophobic active pharmaceutical ingredien...

Jamil A. Aboulhosn, MD, FACC, FSCAI Director, Ahmanson/UCLA Adult Congenital Heart Disease Center Los Angeles, CA This manuscript is intended to provide a brief overview of the indications for and outcomes of surgical and transcatheter interventions for congenital heart disease and pulmonary hypertension (PH). Pulmonary hypertension is frequently encountered in children and adults with congenit...

dans cet article, l'auteur tudie la creation d'une voie ferre interurbaine, de la banlieue ou urbaine, et essaie de d6terminer le nombre optimal de stations pour une longueur donnee de la ligne; compte tenue d'une repartion du trafic, ie long de la ligne en question qui est suppose etre connue. le critere d'optimalisation est le temps total perdu par l'ensemble des usag...

dans cet article i' intervalle entre deux trains successifs a ete etudie en fonction de leur vitesses dans deux cas differents. dans ie premier cas ,on suppose que la vitesse des deux trains a une valeur constante, et on etudie les variations de l'intervalle minimum en fonction de la vitesse on determine la vitesse optimale et on etudie les variations de l'intervalle minimum en f...

background: molecules expressed on the surface of infected erythrocytes (ie) with plasmodium falci-parum play important roles in malaria pathogenesis and immune evasion. some of these molecules are specific adhesive ligands mediating adhesion of ie to the vascular endothelium. in the current study, the antigens exposed on the surface of ie with different isolates and various binding subpopulati...

In the background where there are many factors affecting Japanese families such as decrease of children, change family structures, gender concept, etc., "family'' has become a noticeable issue attracting much attention nowadays. The type traditional named "IE'' was officially regulated in law during Meiji period. After war, legal status eliminated; however, reality, still remains popular. fact,...

BACKGROUND Particulate systems have received increasing attention for oral delivery of biomolecules. The objective of the present study was to prepare submicron particulate formulations of papain for pH-dependent site-specific release using pH-sensitive polymers. METHODS Enteric submicron particle formulations of papain were prepared by w/o/w emulsion solvent evaporation using hydroxypropyl m...