نتایج جستجو برای: il28b polymorphisms

تعداد نتایج: 67261  

2012
Jennifer M. Reynolds Sara A. Paciga Frances A. Sanders Craig L. Hyde A. Katrina Loomis Geoffrey I. Johnston

Several SNPs located in or around the IL28B gene are associated with response of patients infected with Hepatitis C virus to treatment with pegylated interferon-α ⁺/⁻ ribavirin or with spontaneous clearance of the virus. The results of such studies are so compelling that future treatment approaches are likely to involve clinical decisions being made on the basis of a patient's genotype. Since I...

2011

Combination therapy of pegylated interferonwith ribavirin (PEG-IFN/RBV) is a standard of care for chronic hepatitis C (CHC). The majority of CHC patients are infected with HCV genotype I. The recent discovery revealed by a genome-wide association study technology provides the important role of interleukin-28B (IL28B) and inosine triphosphatase (ITPA) in HCV infection. In addition, response to P...

Journal: :The Journal of infectious diseases 2011
Jacob Nattermann Martin Vogel Hans Dieter Nischalke Mark Danta Stefan Mauss Hans-Jörg Stellbrink Axel Baumgarten Christoph Mayr Raffaele Bruno Cristina Tural Gerd Klausen Bonaventura Clotet Uwe Naumann Thomas Lutz Michael Rausch Knud Schewe Bernhard Bienek Georg Haerter Tilman Sauerbruch Juergen K Rockstroh Ulrich Spengler

Recently, a IL28B (rs 12979860) gene polymorphism was identified as a predictor for response to hepatitis C virus-specific treatment in human immunodeficiency virus (HIV)-uninfected and -infected patients with chronic hepatitis C. In an analysis of HIV-infected patients with acute hepatitis C, we found that the IL28B genotype was associated with serum levels of hepatitis C virus RNA, g-GT, and ...

2014
Valli De Re Laura Gragnani Elisa Fognani Alessia Piluso Francesco Izzo Alessandra Mangia Marina Crovatto Graziella Gava Pietro Casarin Domenico Sansonno Vito Racanelli Salvatore De Vita Pietro Pioltelli Laura Caggiari Mariangela De Zorzi Massimiliano Berretta Andrea Gini Antonella Zucchetto Franco Maria Buonaguro Paolo De Paoli Anna Linda Zignego

With the aim of investigating whether interleukin 28B gene (IL28B) rs1297860 polymorphism is associated with different hepatitis C (HCV) infection statuses, we compared IL28B allelic distribution in an Italian case series of 1050 patients with chronic infection and different outcomes, 47 individuals who spontaneously cleared HCV, and 178 blood donors. Furthermore, we compared IL28B variants amo...

Journal: :Antiviral therapy 2015
Karin Neukam Daniela Munteanu Sebastian Haubitz José A Mira Patrick Ingiliz Antonio Rivero-Juárez Thomas Lutz Ignacio de los Santos-Gil Stefan Scholten Manuel Márquez Andri Rauch Jürgen K Rockstroh Juan A Pineda

BACKGROUND IL28B genotype predicts response to treatment against HCV with pegylated interferon/ribavirin (PR) and impacts on the outcome of therapy including telaprevir (TVR). This study aimed to determine the influence of the favourable IL28B genotype on early viral kinetics during therapy with TVR/PR in HIV-HCV-coinfected patients. METHODS All HIV-HCV genotype 1 coinfected subjects who rece...

Journal: :CPT: pharmacometrics & systems pharmacology 2016
L S Wu L C Jimmerson C E MacBrayne J J Kiser D Z D'Argenio

Ribavirin remains an important component of hepatitis C treatment in certain clinical scenarios, but it causes hemolytic anemia. A quantitative understanding of the ribavirin exposure-anemia relationship is important in dose individualization/optimization. We developed a model relating ribavirin triphosphate (RTP) exposure in red blood cells (RBCs), RBC lifespan, feedback regulation of RBC prod...

2012
Mostafa K. El-Awady Lotiaf Mostafa Ashraf A. Tabll Tawfeek H. Abdelhafez Noha G. Bader El Din Naglaa Zayed Reem El Shenawy Yasmin El Abd Reham M. Hasan Hosam Zaghlol Hesham El Khayat Ashraf O. Abdel Aziz

BACKGROUND IL28B single nucleotide polymorphisms (SNPs) play important roles in the management of hepatitis C virus (HCV) infections and are strongly associated with spontaneous and treatment-induced HCV clearance. OBJECTIVES In the present study, the association between IL28B variants and the progression of HCV infection in Egyptian patients infected with type 4a virus will be examined. PA...

Journal: :Asian Pacific journal of cancer prevention : APJCP 2014
Abdel-Rahman N Zekri Hosny Salama Eman Medhat Abeer A Bahnassy Heba M Morsy Mai M Lotfy Rasha Ahmed Tarneem Darwish Mohamad S Marei

BACKGROUND Egypt has one of the highest prevalences of hepatitis C virus (HCV) infection worldwide. Although the IL28B gene polymorphism has been shown to modify the course of chronic HCV infection, this has not been properly assessed in the Egyptian population. MATERIALS AND METHODS The IL28B rs12979860 single nucleotide polymorphism (SNP) was therefore examined in 256 HCV-infected Egyptian ...

2014
Roberta D’Ambrosio Alessio Aghemo Raffaele De Francesco Maria Grazia Rumi Enrico Galmozzi Stella De Nicola Cristina Cheroni Paul J. Clark Guido Ronchi Pietro Lampertico Massimo Colombo

UNLABELLED The interleukin 28B (IL28B) rs12979860 polymorphism is associated with treatment outcome in hepatitis C virus (HCV) genotype 1 and 4 patients. Its association with the histological features of chronic hepatitis C and disease severity needs further clarifications. To assess the correlation between IL28B genotype, HCV genotype and liver biopsy findings in untreated patients. MATERIAL...

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